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Adult stem cells applied to tissue engineering and regenerative medicine
Corresponding Author(s) : J. A. Andrades
andrades@uma.es
Cellular and Molecular Biology,
Vol. 54 No. 1: Cellular engineering
Abstract
Regeneration takes place in the body at a moment or another throughout life. Bone, cartilage, and tendons (the key components of the structure and articulation in the body) have a limited capacity for self-repair and, after traumatic injury or disease, the regenerative power of adult tissue is often insufficient. When organs or tissues are irreparably damaged, they may be replaced by an artificial device or by a donor organ. However, the number of available donor organs is considerably limited. Generation of tissue-engineered replacement organs by extracting stem cells from the patient, growing them and modifying them in clinical conditions after re-introduction in the body represents an ideal source for corrective treatment. Mesenchymal stem cells (MSCs) are the multipotential progenitors that give rise to skeletal cells, vascular smooth muscle cells, muscle (skeletal and cardiac muscle), adipocytes (fat tissue) and hematopoietic (blood)-supportive stromal cells. MSCs are found in multiple connective tissues, in adult bone marrow, skeletal muscles and fat pads. The wide representation in adult tissues may be related to the existence of a circulating blood pool or that MSCs are associated to the vascular system.
Keywords
Stem cell
Cell therapy
Tissue engineering
Regenerative medicine
Chondrogenesis
Osteogenesis.
Cuenca-López, M. D., Zamora-Navas, P., García-Herrera, J. M., Godino, M., López-Puertas, J. M., Guerado, E., Becerra, J., & Andrades, J. A. (2008). Adult stem cells applied to tissue engineering and regenerative medicine. Cellular and Molecular Biology, 54(1), 40–51. Retrieved from http://mail.cellmolbiol.org/index.php/CMB/article/view/1035
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