Nidhi  Naik; Radhey Shyam  Kaushal; Tarun Kumar Upadhyay Upadhyay; Danial Kahrizi; Mohammad A A  Al-Najjar; Mohammad Suhail  Khan; Samra  Siddiqui

doi:10.14715/cmb/2022.68.10.19

Issue

Vol. 68 No. 10: Issue 10

Issue Published : March 31, 2023

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Role of Natural plant extracts for potential Antileishmanial targets–In-depth review of the molecular mechanism

Natural plant extract – potential targets for leishmaniasis

https://doi.org/10.14715/cmb/2022.68.10.19

Nidhi Naik

Department of Life Sciences, Parul Institute of Applied Sciences and Center of Research for Development, Parul University, Vadodara, Gujarat, India – 391760

Radhey Shyam Kaushal

Department of Life Sciences, Parul Institute of Applied Sciences and Center of Research for Development, Parul University, Vadodara, Gujarat, India – 391760

Tarun Kumar Upadhyay Upadhyay

Parul University, Vadodara, Gujarat

Danial Kahrizi

Agricultural Biotechnology Department, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran

Mohammad A A Al-Najjar

Department of Pharmaceutical Sciences and Pharmaceutics. Faculty of Pharmacy, Applied Science Private University, Amman. Jordan

Mohammad Suhail Khan

Department of Public Health, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid, University, Abha, Saudi Arabia

Samra Siddiqui

Department Health Services Management, College of Public Health and Health Informatics, University of Hail, Hail, Saudi Arabia

Corresponding Author(s) : Radhey Shyam Kaushal

radheynature07@gmail.com

Cellular and Molecular Biology, Vol. 68 No. 10: Issue 10
Article Published : September 30, 2022

Abstract

A group of protozoan parasites known as Leishmania species can cause a variety of chronic illnesses, ranging from self-healing lesions to fatal outcomes. Drug-resistant pathogens have become common due to the lack of safe and effective medications, which has sparked the development of new therapeutic interventions, particularly plant-based natural extracts. As a way to avoid chemotherapy's side effects, natural herbal remedies have drawn more attention. In addition to having anti-inflammatory, anticancer, and cosmetic properties, the secondary metabolites of plants, such as phenolic compounds, flavonoids, alkaloids, and terpenes, have a number of positive effects on our health. Natural metabolites such as naphthoquinone, alkaloids, benzophenones, etc. that have antileishmanial and antiprotozoal activity have been the subject of extensive research. In this review paper, it can be concluded that these natural extracts can be developed into excellent therapeutic agents against Leishmaniasis.

Keywords

Alkaloids, Leishmaniasis,Natural Extract,n-Butanol, n-Hexane, Phenolic Compounds

Naik, N. ., Kaushal, R. S. ., Upadhyay, T. K. U., Kahrizi, D., Al-Najjar, M. A. A. ., Khan, M. S. ., & Siddiqui, S. . (2022). Role of Natural plant extracts for potential Antileishmanial targets–In-depth review of the molecular mechanism: Natural plant extract – potential targets for leishmaniasis. Cellular and Molecular Biology, 68(10), 117–123. https://doi.org/10.14715/cmb/2022.68.10.19