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Copyright (c) 2022 Shen Wenwen, Liang Xiquan, Lin Aiqin
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Risk factors of carbapenem-resistant gram-negative bacteria pneumonia and mortality
Corresponding Author(s) : Lin Aiqin
Cellular and Molecular Biology,
Vol. 68 No. 10: Issue 10
Abstract
This experiment aimed to study the risk factors of carbapenem-resistant Gram-negative bacteria pneumonia and death. For this aim, a total of 181 patients with Gram-negative bacterial pneumonia treated from March 2020 to March 2022 were retrospectively selected and divided into the drug-resistance group (n = 96) and the non-drug resistance group (n = 85) according to the carbapenem resistance. According to the prognosis, the drug resistance group was divided into the survival group (n = 82) and the non-survival group (n = 14), respectively. The risk factors of single and multi-factor carbapenem-resistant Gram-negative bacteria pneumonia and death were studied. Results showed that univariate analysis showed that the rates of recent surgery, respiratory failure, shock, indwelling catheterization and disturbance of consciousness were significantly higher in the drug-resistant group than in the non-drug-resistant group. The univariate analysis also showed that the rates of coronary heart disease, diabetes, shock, renal insufficiency, deep venous catheterization and respiratory failure were significantly higher in the non-survival group than in the survival group. Multivariate analysis showed an increased risk of carbapenem-resistant gram-negative pneumonia in patients who had used carbapenem-resistant antibiotics, hypertension, coronary heart disease, and malignancy in the previous 90 days. Patients with carbapenem-resistant gram-negative pneumonia who had coronary heart disease, diabetes mellitus, shock, renal insufficiency, deep venous catheterization, and respiratory failure were at increased risk of death. In conclusion, recent surgery, respiratory failure, shock, indwelling catheterization, and disturbance of consciousness are risk factors for carbapenem-resistant Gram-negative bacteria pneumonia. Coronary heart disease, diabetes mellitus, shock, renal insufficiency, deep venous catheterization and respiratory failure are risk factors for death from carbapenem-resistant gram-negative bacteria pneumonia.
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