The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview
Corresponding Author(s) : M. Armand
martine.armand@univ-amu.fr
Cellular and Molecular Biology,
Vol. 59 No. 1: Effects of milk bioactive compounds on health
Abstract
Premature births are increasing worldwide (about 15 millions per year) due to several reasons (an advanced maternal age, fertility treatments, stress, smoking, nutritional deficiencies) and lead to a high societal overall cost. Among neonatal care procedures, the clinical nutrition practices are essential to promote the development and to minimize the sequelae. Premature newborns are at major risk of death by infections due to the immaturity of their intestine. Human milk provides not only nutrients but also a plethora of biologically active components that are tailored to contribute to the development of the intestinal tract early in postnatal life. Among them, some bioactive molecules exhibit trophic effects (LC-PUFA, sphingomyelin, IGF-I and IGF-II, EGF, insulin, leptin, adiponectin, lactoferrin, lactadherin, probiotics, prebiotics, miRNA) or are part of the intestinal cell membranes (PUFA, LC-PUFA, phospholipids, sphingolipids, cholesterol), others educate the intestine for innate microbial recognition (sCD14, sTLR-2, miRNA), many of them display direct fighting against pathogens (some fatty acids and monoglycerides, some phospholipids and sphingolipids, BSSL, insulin, lactoferrin, sIgAs, MUC-1, lactadherin, probiotics, prebiotics), or contribute to establish the gut microbiota (LC-PUFA, lactoferrin, probiotics, prebiotics). A synergetic action exists between several bioactive molecules. All together these precious agents regulate the maturation of the intestinal mucosal barrier, and might program early in postnatal life the future adult intestinal health. This review lists the main bioactive compounds and addresses their plausible roles and mechanisms of action.
Keywords
Human milk
phospholipids
sphingolipids
cholesterol
DHA
sphingomyelinase
sCD14
milk growth factors
milk hormones
lactoferrin
MUC-1
lactadherin
prebiotics
probiotics
miRNA
premature newborn
intestine
necrotizing enterocolitis.
Garcia, C., Duan, R. D., Brévaut-Malaty, V., Gire, C., Millet, V., Simeoni, U., Bernard, M., & Armand, M. (2013). Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cellular and Molecular Biology, 59(1), 108–131. Retrieved from http://mail.cellmolbiol.org/index.php/CMB/article/view/488
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX