Tianyi Zhu; Hao Liu; Lan Ling; Yang Wang; Chao Jin; Jirong Qi; Chen Zhou

doi:10.14715/cmb/2023.69.10.22

Issue

Vol. 69 No. 10: Issue 10

Issue Published : October 31, 2023

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Mendelian randomization study of IGF-1, childhood obesity and obesity-related asthma

Relationship between IGF-1 and childhood obesity-related asthma

https://doi.org/10.14715/cmb/2023.69.10.22

Tianyi Zhu

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Hao Liu

Department of infection, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Lan Ling

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Yang Wang

Department of Cardiothoracic Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Chao Jin

Department of Outpatient, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Jirong Qi

Department of Cardiothoracic Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Chen Zhou

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu,210003, China

Corresponding Author(s) : Chen Zhou

zhouchenvv0126@126.com

Cellular and Molecular Biology, Vol. 69 No. 10: Issue 10
Article Published : October 31, 2023

Abstract

Insulin-like growth factor 1 (IGF-1) has been reported to potentially link with childhood obesity and obesity-related asthma, although a causal effect has not been illustrated. This study aimed to assess their association via multi-variable Mendelian randomization (MR) analysis with two-sample summary-level data on genetic variants as instrumental variables, thus estimating a causal effect. Genetic variants associated with serum IGF‐1 at genome‐wide significance (GWS) in the UK Biobank study involving 363,228 individuals of European descent were introduced as instrumental variables. Summary-level data on childhood obesity and obesity-related asthma were obtained from genome-wide association studies (GWAS). Here, MR-Egger, inverse-variance weighted (IVW), simple median, weighted median and penalized weighted median methods were used in the MR study. Results showed that there were strong causal associations of IGF-1 with childhood obesity (OR, 1.27; 95% CI 1.01-1.60; P<0.05) and obesity-related asthma (OR, 1.22; 95% CI 1.07-1.38; P<0.005). In conclusion, A causal association between high IGF-1 levels and high risks of childhood obesity and obesity-related asthma is estimated, which requires further validation in large-scale trials.

Keywords

IGF-1, childhood obesity, obesity-related asthma, Mendelian randomization

Zhu, T., Liu, H., Ling, L., Wang, Y., Jin, C., Qi, J., & Zhou, C. (2023). Mendelian randomization study of IGF-1, childhood obesity and obesity-related asthma: Relationship between IGF-1 and childhood obesity-related asthma. Cellular and Molecular Biology, 69(10), 155–159. https://doi.org/10.14715/cmb/2023.69.10.22