Issue
Copyright (c) 2025 Hassan A. Madkhali, Majid A. Ganaie , Mohd Nazam Ansari , Najeeb Ur Rehman , Abubaker M. Hamad, Gamal A. Soliman , Khalid F. Alanazi , Mohammed M. Ahmed , Abdullah Y. Hamadi , Naif M. Alhawiti
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Rutin treatment alleviates obesity-related aortic endothelium dysfunction in albino rats fed a high-fat diet
Corresponding Author(s) : Hassan A. Madkhali
Cellular and Molecular Biology,
Vol. 71 No. 7: Issue 7
Abstract
Flavonoids have recently been shown to be useful to people suffering from vascular disorders caused by a high-fat diet (HFD). The flavonoid rutin (RT) exhibits numerous pharmacological effects, including antioxidant, cytoprotective, vasoprotective, and cardioprotective activities. The primary objective of this research was to assess the efficacy of RT against obesity-related vascular endothelial dysfunction (VED) in rats fed HFD. A total of 24 mature Wistar rats were blindly categorized into 4 treatment and control groups: normal control, obese control, and obese which were given RT at 50 and 100 mg/kg for the final 3 weeks of the experimental period. Animals' body mass and food consumption have been estimated periodically. In addition, liver mass and retroperitoneal fat mass per body mass, abdominal circumference (AC), LEE index, and body mass index (BMI) were estimated. Moreover, lipid profile parameters were assessed in serum. The effect on vascular endothelium reactivity was investigated in an isolated rat aorta. A histopathological investigation of the aorta was performed. The obese control group exhibited higher body, liver, and retroperitoneal fat weights. Significantly, RT intake reverses all these alterations. Furthermore, RT decreased food intake, AC, Lee index, and BMI in HFD-fed rats. The lipid profile of HFD-fed rats was also improved after RT treatment, with lower triglycerides, total cholesterol, LDL-C, and VLDL-C levels and higher HDL-C levels in the serum of HFD-fed rats. Through the ex-vivo investigation, RT groups showed improved vascular endothelium function in HFD-fed animals compared to the obese control group. Taking together, RT could be a promising option for preventing obesity-associated VED.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
