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Copyright (c) 2025 RAJAA EL MANSOURI, Prof. HABBAL RACHIDA

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The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Risk factors for coronary in-stent restenosis in Moroccan patients: a retrospective case-control study
Corresponding Author(s) : Rajaa El Mansouri
Cellular and Molecular Biology,
Vol. 71 No. 8: Issue 8
Abstract
In-stent restenosis remains a significant challenge in interventional cardiology despite technological advancements. This retrospective case-control study conducted at the University Hospital Center Ibn Rochd in Casablanca (2020-2023) examined risk factors associated with coronary in-stent restenosis in 68 patients equally distributed between restenosis and no-restenosis groups. Diabetes emerged as a powerful predictor of restenosis (RR=4.15, 95% CI [1.05-16.4]), with notable differences in lipid profiles between groups. Restenosis patients exhibited significantly higher LDL cholesterol (2.19 vs. 1.31 mmol/L, p<0.001) and lower HDL levels. Univariate logistic regression identified multiple significant factors, including medication intake duration (OR=1.30, 95% CI [1.09-1.54], p=0.003) and LDL levels (OR=26.7, 95% CI [5.03-141.8], p<0.001). Dual antiplatelet therapy duration differed significantly between groups (p<0.001), while stent characteristics showed no significant differences. Our findings highlight diabetes mellitus as a critical determinant of coronary in-stent restenosis, operating synergistically with specific lipid abnormalities. These results underscore the need for targeted preventive strategies in diabetic patients undergoing percutaneous coronary intervention, including aggressive glycemic control, intensive lipid management, and optimized antiplatelet therapy regimens. The pronounced relationship between diabetes and restenosis emphasizes the importance of individualized approaches to coronary intervention in this high-risk population.
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