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Copyright (c) 2025 Zainab Nizar Jawad
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The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Expression analysis of C-FOS and XRCC3 Thr241Met polymorphism in gastric cancer
Cellular and Molecular Biology,
Vol. 71 No. 8: Issue 8
Abstract
Gastric cancer is one of the causes of deaths related to cancer across the globe and both genetic and environmental
factors are the most prominent. Causes of its pathogenesis. This paper researches the expression
of the C-FOS gene. and Thr241Met talking in the XRCC3 gene in patients with gastric cancer and healthy
individuals. Controls, in an attempt to clarify their behavior as possible disease susceptibility molecular markers.
A total of 100 gastric cancer patients and 100 matched healthy individuals were enrolled, with genomic
DNA and RNA extracted from blood samples. Quantitative real-time PCR was used to assess C-FOS expression,
while PCR-RFLP determined XRCC3 Thr241Met genotypes. The C-FOS and the Thr/Met XRCC3
genotypes, 12 genotypes revealed that C-FOS was significantly overexpressed in patients than in controls (P
<0.001). The XRCC3 Thr/Met genotype was very frequent in patients, as well (P =0.0020). Also, blood type
A, family history of gastric cancer, and residing in the country were shown to be categorized as major factors
of the risk, and were not significant factors. These results indicate that upregulation of C-FOS and the XRCC3
Thr241Met variant are risk factors of gastric cancer and that blood type and familial history are additional
risk factors. We present in our findings that molecular profiling coupled with demographic profiling is highly
relevant in risk assessment and early detection techniques in gastric cancer. The study contributes to the
further comprehension of the molecular pathogenesis of gastric carcinogenesis and suggests C-FOS and
XRCC3 as possible clinical and epidemiological markers.
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