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Copyright (c) 2025 Rezvaneh Ghadyani, Zahra Mozooni, Zihab Sohbatzadeh, Latif Gachkar, Abolfazl Movafagh
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Expression patterns and clinical significance of MMP-8, MMP-9 and MMP-13 in colorectal cancer
Corresponding Author(s) : Abolfazl Movafagh
Cellular and Molecular Biology,
Vol. 71 No. 9: Issue 9
Abstract
Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal system in the world. By identifying specific gene expression patterns that indicate CRC in the early stages, it is possible to potentially diagnose the disease in the early stages and start treatment quickly. Matrix metalloproteinases (MMPs) play a crucial role in the degradation of the extracellular matrix and tissue remodeling. Among them, MMP-8, MMP-9 and MMP-13 have been found to be upregulated in various cancers, including CRC, and are associated with tumor invasion, metastasis, and angiogenesis. This study investigated tissue expressions of MMP-8, MMP-9, and MMP-13 in CRC patients and explored their possible associations with pathological and clinical factors. 100 patients with CRC and 100 control subjects were involved in the study. Tissue and blood samples were collected. The quantitative Real-Time PCR (qRT-PCR) technique was used to assess the expression levels of the MMP-8, MMP-9, and MMP-13 in CRC tissue samples in comparison with the adjacent control tissue. Our results revealed that the expression levels of MMP-8, MMP-9, and MMP-13 were significantly up-regulated in CRC tissues compared to the adjacent control group. Analysis of patients' clinicopathological features showed a statistically significant difference in the expression levels of MMP-8, MMP-9, and MMP-13 between CRC patients with and without lymphovascular invasion (LVI) and TMN stage. ROC curve results have shown that these genes are good candidate diagnostic biomarkers in CRC. These results indicated that MMP-8, MMP-9, and MMP-13 levels may serve as potential diagnostic biomarkers for CRC.
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