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Copyright (c) 2025 Zahraa Abdulhadi Nima , Orass Madhi Shaheed
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Exploring miR-222-3p and miR-16-5p: promising biomarkers for gestational diabetes mellitus diagnosis
Corresponding Author(s) : Zahraa Abdulhadi Nima
Cellular and Molecular Biology,
Vol. 71 No. 10: Issue 10
Abstract
Gestational diabetes mellitus (GDM) is a common complication during pregnancy, associated with various adverse maternal and fetal outcomes. Women with GDM have increased risks of cesarean delivery, pre-eclampsia, and gestational hypertension. Additionally, GDM raises the risk of impaired glucose metabolism, obesity, and cardiovascular diseases. This study enrolled 100 pregnant women under medical supervision at the Maternity and Children's Teaching Hospital in Al-Diwaniyah Governorate from September 5, 2024, to May 28, 2025, including 50 diagnosed with GDM and 50 healthy controls. There was no significant difference in mean age between the groups, although GDM patients tended to be slightly older. Expression levels of miR-222-3p and miR-16-5p were measured by quantitative real-time PCR. The mean Ct value for miR-222-3p was significantly lower in GDM patients (26.70) compared to controls (28.79), indicating higher expression in the patient group. Conversely, expression of miR-16-5p was reduced in GDM patients relative to controls. Our findings suggest that elevated miR-222-3p and decreased miR-16-5p levels in maternal blood may serve as promising biomarkers for early diagnosis and risk assessment of GDM.
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