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Copyright (c) 2025 Seshadri Reddy Varikasuvu, Sadhana Sharma, Prateek Banerjee, Subodh Kumar, Saurabh Varshney, Pratima Gupta, Shiv Kumar Mudgal, Mona Lisa, Ranwir Kumar Sinha, Nikhil Kumar, Nishi, Prima Shuchita Lakra, Sanjeet Kumar Singh, Harishkumar Rameshkumar Bohra, Anandraj Vaithy, Nidhi Priya Allie Barla, Anila Sinha
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Clinical significance of B7-H4 expression in ovarian cancer: a meta-analysis of proportions and time-to-event survival outcomes
Corresponding Author(s) : Seshadri Reddy Varikasuvu
Cellular and Molecular Biology,
Vol. 71 No. 10: Issue 10
Abstract
B7-H4 is an immune-regulatory molecule increasingly recognized for its role in tumor progression and immune evasion in epithelial ovarian cancer. To clarify its clinical relevance, we conducted a systematic review and meta-analysis evaluating the prevalence of B7-H4 expression and its association with survival outcomes. Nineteen eligible studies were included, of which sixteen provided data on expression proportions and eight reported progression-free or overall survival outcomes. The pooled prevalence of high or positive B7-H4 expression was 73%, though with considerable inter-study variability. High B7-H4 expression was associated with a significantly increased risk of disease progression (pooled unadjusted hazard ratio: 1.43), while its relationship with overall survival remained inconclusive due to limited data. Despite methodological differences among studies, the findings suggest B7-H4 is overexpressed and potentially prognostic in ovarian cancer. Additional studies are required to validate its clinical utility in patient risk assessment and as a therapeutic target.
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