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Copyright (c) 2025 Ayat Salim Khaleel, Abeer Cheaid Yousif Al-Fatlawi, Wasan Ghazi Abood Al-Safi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Evaluation of heat shock protein 70, AMH, and key hormonal markers in cellular mechanisms of polycystic ovary syndrome
Corresponding Author(s) : Ayat Salim Khaleel
Cellular and Molecular Biology,
Vol. 71 No. 10: Issue 10
Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases characterized by hyperandrogenemia and anovulation. The present study aimed to estimate heat shock protein 70 (HSP-70) in PCOS patients. This case-control study involved 90 females aged 15 to 45 years, divided into two groups: 45 controls and 45 PCOS patients. Levels of HSP-70, anti-Müllerian hormone (AMH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, and testosterone were measured using enzyme-linked immunosorbent assay (ELISA). The study revealed a significant increase (p ≤ 0.01) in HSP-70 and AMH levels in PCOS patients compared to controls, with mean ± SD values of 16.49 ± 2.79 and 2386.14 ± 530.09, respectively. Hormonal parameters such as LH, testosterone, and prolactin were elevated, whereas FSH was decreased in PCOS patients. The findings suggest that elevated HSP-70 plays a key role in the pathogenesis of PCOS.
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