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Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes.
Corresponding Author(s) : Y. Yang
yyang@sookmyung.ac.kr
Cellular and Molecular Biology,
Vol. 56 No. 3: General Papers
Abstract
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-α and peroxisome proliferator activated receptor-γ, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPARγ and C/EBPα and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
Keywords
C/EBPα
PPARγ
Adiponectin
Asarone
Hormone-sensitive lipase
Lee, S. H., Kim, K.-Y., Ryu, S. Y., Yoon, Y., Hahm, D.-H., Kang, S. A., Cho, S. H., Lim, J.-S., Moon, E.-Y., Yoon, S. R., Lee, H. G., Yoon, D. Y., & Yang, Y. (2010). Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes. Cellular and Molecular Biology, 56(3), 1215–22. Retrieved from http://mail.cellmolbiol.org/index.php/CMB/article/view/967
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