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Expression of cell adhesion molecule L1 in the long head of biceps tendon
Corresponding Author(s) : K. Alpantaki
apopaki@yahoo.gr
Cellular and Molecular Biology,
Vol. 56 No. 3: General Papers
Abstract
Several studies have proposed that the nervous system participates in nociception and tendon healing process. The neural cell adhesion molecule L1 (L1-CAM), which has an important role in neural development and nociceptive pathways, has been described in the past in the skeletal muscles and tendino-muscular junction. The role of this protein in tendon pathology is unknown. Here, we show that L1-CAM is expressed in human tendons. Samples of the long head of the biceps tendon (LHB) from six patients undergoing shoulder surgery were studied. Both Western blot and immunofluorescence revealed a strong expression pattern of L1-CAM. These L1-CAM positive cells were also Tuj1 positive, suggesting a neuronal origin. To our knowledge this is the first unequivocal evidence of the presence of L1 CAM in human tendons suggesting that it may play a role in organization of extracellular matrix and tendon pain.
Keywords
Tendon of long head of biceps
L1-CAM
shoulder pain
tendinosis.
Alpantaki, K., Savvaki, M., & Karagogeos, D. (2010). Expression of cell adhesion molecule L1 in the long head of biceps tendon. Cellular and Molecular Biology, 56(3), 1286–89. Retrieved from http://mail.cellmolbiol.org/index.php/CMB/article/view/975
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