Issue

Vol. 63 No. 10: Issue 10

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Circulating macrophage migration inhibitory factor levels and its polymorphisms in systemic lupus erythematosus: A meta-analysis

https://doi.org/10.14715/cmb/2017.63.10.12
S-C. Bae
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Division of Rheumatology, Seoul, Korea
Y. H. Lee
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

Corresponding Author(s) : Y. H. Lee

lyhcgh@korea.ac.kr

Cellular and Molecular Biology, Vol. 63 No. 10: Issue 10

Abstract

The present study aimed to systemically review the evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and systemic lupus erythematosus (SLE), as well as the associations between several polymorphisms in the MIF gene and SLE susceptibility. We performed a meta-analysis of serum/plasma levels of MIF in SLE patients and controls and evaluated evidence of associations between the MIF -173 C/G allele and -794CATT5-8 polymorphisms and the associated risk for SLE. Nine studies were included in this meta-analysis. Meta-analysis indicated that MIF levels were significantly higher in the SLE group than in the control group (SMD = 1.154, 95% CI = 0.369–1.938, P = 0.004). Stratification by ethnicity showed significantly higher MIF levels in the SLE group representing Asian populations (SMD = 1.911, 95% CI = 0.871–2.951, P < 0.001). MIF levels were significantly higher in the SLE group than in the control group in the age-and/or sex matched population, but not in the unmatched population (SMD = 1.236, 95% CI = 0.579–1.893, P < 0.001; SMD = 1.118, 95% CI = -0.027–2.263, P = 0.056). However, results of the meta-analysis showed no association between SLE and the MIF -173 C allele, the -794CATT7 allele, and the -794CATT7-MIF-173C haplotype with high heterogeneity. Our meta-analysis demonstrated significantly higher circulating MIF levels in patients with SLE, but no evidence of associations between MIF -173 C/G and -794CATT5-8 polymorphisms and SLE susceptibility.

Keywords

MIF Level Polymorphism SLE.
Bae, S.-C., & Lee, Y. H. (2017). Circulating macrophage migration inhibitory factor levels and its polymorphisms in systemic lupus erythematosus: A meta-analysis. Cellular and Molecular Biology, 63(10), 74–79. https://doi.org/10.14715/cmb/2017.63.10.12
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Kotzin BL. Systemic lupus erythematosus. Cell. 1996;85(3):303-6.
  2. Donnelly SC, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today. 1997;3(11):502-7.
  3. Kasama T, Ohtsuka K, Sato M, Takahashi R, Wakabayashi K, Kobayashi K. Macrophage migration inhibitory factor: a multifunctional cytokine in rheumatic diseases. Arthritis. 2011;2010.
  4. Leech M, Lacey D, Xue JR, Santos L, Hutchinson P, Wolvetang E, et al. Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis & Rheumatology. 2003;48(7):1881-9.
  5. Lang T, Foote A, Lee JP, Morand EF, Harris J. MIF: implications in the pathoetiology of systemic lupus erythematosus. Frontiers in immunology. 2015;6:577.
  6. Budarf M, McDonald T, Sellinger B, Kozak C, Graham C, Wistow G. Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11. 2. Genomics. 1997;39(2):235-6.
  7. Donn R, Alourfi Z, De Benedetti F, Meazza C, Zeggini E, Lunt M, et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46(9):2402-9.
  8. Baugh J, Chitnis S, Donnelly S, Monteiro J, Lin X, Plant B, et al. A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes and immunity. 2002;3(3):170-6.
  9. Feng X, Chen W, Xiao L, Gu F, Huang J, Tsao B, et al. Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus. Lupus. 2017;26(1):62-72.
  10. Guan Y, Zhang Y, Fang M, Guan J, Sun X, Zhang J. The relationship between mRNA level of glucocorticoid receptor α, heat shock protein 90, protein level of macrophage migration inhibitory factor and glucocorticoid resistance in systemic lupus erythematosus. Zhonghua nei ke za zhi. 2015;54(11):922-6.
  11. De la Cruz-Mosso U, Bucala R, Palafox-Sanchez C, Parra-Rojas I, Padilla-Gutierrez J, Pereira-Suarez A, et al. Macrophage migration inhibitory factor: association of− 794 CATT 5–8 and− 173 G> C polymorphisms with TNF-α in systemic lupus erythematosus. Human immunology. 2014;75(5):433-9.
  12. Wang F-F, Zhu L-A, Zou Y-Q, Zheng H, Wilson A, Yang C-D, et al. New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus. Arthritis research & therapy. 2012;14(3):R103.
  13. Sreih A, Ezzeddine R, Leng L, LaChance A, Yu G, Mizue Y, et al. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis & Rheumatism. 2011;63(12):3942-51.
  14. Chen W, Li G, Fang F, Yang X, He X, Zhou F, et al. The expression of migration inhibitory factor in peripheral blood mononuclear cell and its correlation with disease activity in systemic lupus erythematosus. Zhonghua nei ke za zhi. 2004;43(8):572-5.
  15. Foote A, Briganti EM, Kipen Y, Santos L, Leech M, Morand EF. Macrophage migration inhibitory factor in systemic lupus erythematosus. The Journal of rheumatology. 2004;31(2):268-73.
  16. YUKAMIZUE JN, MIYAZAKI T, FUJIWARA S, CHIDA M, KENJINAKAMURA KK, MUKAI M. Quantitation of macrophage migration inhibitory factor (MIF) using the one-step sandwich enzyme immunosorbent assay: elevated serum MIF concentrations in patients with autoimmune diseases and identification of MIF in erythrocytes. International journal of molecular medicine. 2000;5:397-403.
  17. Sanchez E, Gomez L, Lopez-Nevot M, Gonzalez-Gay M, Sabio J, Ortego-Centeno N, et al. Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. Genes and immunity. 2006;7(5):433-6.
  18. Song GG, Lee YH. Comparison of disease activity score 28 using C-reactive protein and disease activity score 28 using erythrocyte sedimentation rate in assessing activity and treatment response in rheumatoid arthritis: a meta-analysis. Journal of Rheumatic Diseases. 2016;23(4):241-9.
  19. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
  20. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC medical research methodology. 2005;5:13.
  21. Ridout KK, Ridout SJ, Price LH, Sen S, Tyrka AR. Depression and telomere length: A meta-analysis. Journal of affective disorders. 2016;191:237-47.
  22. Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures. BMJ. 1997;315(7121):1533-7.
  23. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.
  24. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
  25. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629-34.
  26. Feng X, Huang J, Li R, Sun L. Association of elevated interferon-inducible gene expressions with proatherosclerotic factors in Sle patients. International Journal of Rheumatic Diseases. 2010;13:120.
  27. Connelly K, Kandane-Rathnayake R, Hoi A, Nikpour M, Morand E. Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus. Scientific Reports. 2016;6.
  28. Feng X, Chen W, Sun L. THU0281 Artesunate Inhibits Type I Interferon Induced Production of Macrophage Migration Inhibitory Factor in Patients with Systemic Lupus Erythematosus. Annals of the Rheumatic Diseases. 2016;75(Suppl 2):288-9.
  29. Hoi AY, Hickey MJ, Hall P, Yamana J, O'Sullivan KM, Santos LL, et al. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. The Journal of Immunology. 2006;177(8):5687-96.
  30. Donn R, Alourfi Z, De Benedetti F, Meazza C, Zeggini E, Lunt M, et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis & Rheumatism. 2002;46(9):2402-9.
  31. Donn R, Alourfi Z, Zeggini E, Lamb R, Jury F, Lunt M, et al. A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis & Rheumatism. 2004;50(5):1604-10.
  32. Lee YH, Bae S-C, Song GG. The association between the functional PTPN22 1858 C/T and MIF− 173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis. Inflammation Research. 2012;61(5):411-5.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 812 Download : 437