Issue

Vol. 64 No. 5: Issue 5

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Association between polymorphisms of glucocorticoid receptor genes and asthma: A meta-analysis

https://doi.org/10.14715/cmb/2018.64.5.3
Guanglei Fu
Emergency Department, the first Affiliated Hospital of Jinan University, Guangzhou 510006, China
Lijun Fu
Department of anesthesiology, Shenzhen Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, China
Youli Cai
South China Research Center for Acupuncture and Moxibustion, School of basic medical science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
Hui Zhao
South China Research Center for Acupuncture and Moxibustion, School of basic medical science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
Wenjun Fu
South China Research Center for Acupuncture and Moxibustion, School of basic medical science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

Corresponding Author(s) : Wenjun Fu

w502956@163.com

Cellular and Molecular Biology, Vol. 64 No. 5: Issue 5

Abstract

Recent studies have evaluated the associations between polymorphisms of glucocorticoid receptor genes and asthma. However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of glucocorticoid receptor genetic loci and susceptibility to asthma, based on existing reports. We conducted a meta-analysis of the association between glucocorticoid receptor polymorphisms (NR3C1) and asthma risk. A systematical literature search was performed in PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library until January 15, 2018. The odds ratio (OR), 95% confidence interval (CI), and P value were calculated using Mantel-Haenszel statistics under the allele, homozygote, heterozygote, dominant, or recessive models. P values of less than 0.05 were considered to represent statistically significant associations between glucocorticoid receptor gene polymorphisms and asthma. All statistical analyses were done using the "meta” package (version 4.9–0) of R version 3.4.3 and RStudio version 1.0.44. A total of fourteen studies, reported via ten articles from online databases were included in our meta-analysis. For BclI (from eight studies), a significant association was detected in the allele model, homozygote model, and recessive model (C versus G: OR (95% CI) = 0.63 (0.40–0.97), CC versus GG: OR (95% CI) = 0.41(0.17–0.97), CC versus GC + GG: OR (95% CI) = 0.54(0.34–0.88)), but not in the heterozygote model or the dominant model. For ER22/23EK (from four studies), TthIII1 (from two studies), no significant association was found for any genetic model. After subgroup analyses by age, significant associations were observed for the allele model, homozygote model, dominant model and recessive model for BclI in adults. The ER22/23EK and TthIII1 polymorphisms were not found to be associated with susceptibility to ASTHMA; however, the BclI polymorphisms were significantly associated with ASTHMA in adults.

Keywords

Glucocorticoid receptor Gene polymorphisms Asthma.
Fu, G., Fu, L., Cai, Y., Zhao, H., & Fu, W. (2018). Association between polymorphisms of glucocorticoid receptor genes and asthma: A meta-analysis. Cellular and Molecular Biology, 64(5), 13–23. https://doi.org/10.14715/cmb/2018.64.5.3
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Thomson NC. New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert opinion on pharmacotherapy 2017; 18(3): 283-293.
  2. Meakin AS, Saif Z, Jones AR, Aviles PFV, Clifton VL. Review: Placental adaptations to the presence of maternal asthma during pregnancy. Placenta Jun 2017; 54: 17-23.
  3. Chang HS, Lee TH, Jun JA et al. Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations. Expert Review Of Respiratory Medicine 2017; 11(1): 29-40.
  4. Junchao Y, Zhen W, Yuan W et al. Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor alpha. The Journal of international medical research Feb 2017; 45(1): 101-113.
  5. Nyenhuis SM, Krishnan JA, Berry A et al. Race is associated with differences in airway inflammation in patients with asthma. Journal Of Allergy And Clinical Immunology Jul 2017; 140(1): 257-+.
  6. Mukherjee M, Svenningsen S, Nair P. Glucocortiosteroid subsensitivity and asthma severity. Current Opinion In Pulmonary Medicine Jan 2017; 23(1): 78-88.
  7. Barnes PJ. Glucocorticosteroids. Handbook of experimental pharmacology 2017; 237: 93-115.
  8. Chachi L, Gavrila A, Tliba O, Amrani Y. Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma. Clinical And Experimental Allergy Nov 2015; 45(11): 1637-1646.
  9. Annane D, Bellissant E, Bollaert Pierre E, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating sepsis. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2015.
  10. Adcock IM, Mumby S. Glucocorticoids. Handbook of experimental pharmacology 2017; 237: 171-196.
  11. Normansell R, Kew Kayleigh M, Mansour G. Different oral corticosteroid regimens for acute asthma. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2016.
  12. Sagoo GS, Little J, Higgins JP. Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS medicine Mar 3 2009; 6(3): e28.
  13. Stroup DF, Berlin JA, Morton SC et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA Apr 19 2000; 283(15): 2008-2012.
  14. Wells GA, Shea BJ, O'Connell D et al. The Newcastle–Ottawa Scale (NOS) for Assessing the Quality of Non-Randomized Studies in Meta-Analysis. Applied Engineering in Agriculture 2014; 18(6): págs. 727-734.
  15. Schaid DJ, Jacobsen SJ. Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. American journal of epidemiology Apr 15 1999; 149(8): 706-711.
  16. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ (Clinical research ed) Sep 6 2003; 327(7414): 557-560.
  17. Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genetic epidemiology Feb 2005; 28(2): 123-137.
  18. Thakkinstian A, McElduff P, D'Este C, Duffy D, Attia J. A method for meta-analysis of molecular association studies. Statistics in medicine May 15 2005; 24(9): 1291-1306.
  19. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in medicine Jun 15 2002; 21(11): 1539-1558.
  20. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) Sep 13 1997; 315(7109): 629-634.
  21. Szczepankiewicz A, Breborowicz A, Sobkowiak P, Popiel A. No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids. Advances in medical sciences 2008; 53(2): 245-250.
  22. Cheng Z, Dai LL, Liu Q et al. Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province. Genetics and molecular research : GMR Jun 3 2016; 15(2).
  23. Pietras T, Panek M, Tworek D et al. The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study. Molecular biology reports 2011; 38(6): 3953-3958.
  24. Morales M, Flores C, Pino K, Angulo J, López-Lastra M, Castro-Rodriguez JA. Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma. Allergologia et immunopathologia 2015; 44(1): 59-65.
  25. Kmyta VV, Garbuzova VY, Prystupa EN, Prystupa LN. Bcl1 polymorphism of glucocorticoid receptor gene in patients with bronchial asthma with obesity. Cytology & Genetics 2016; 50(3): 178-182.
  26. Yun ZL, Wang DM, Qu Y. [Relationship between bronchial asthma and glucocorticoid receptor bcl-I single nucleotide polymorphism]. Journal of Clinical Medicine in Practice 2016; 20(11): 21-24.
  27. Fan F, Bao Y, Liu Q, Hua L. [Association of the glucocorticoid receptor gene polymorphisms with childhood asthma in Han nationality]. Chinese Journal of Practical Pediatrics 2013; 28(2): 114-117.
  28. Liu B, Zhang S, Chen Y. [Study on the relationship between glucocorticoid receptor gene polymorphism and bronchial asthma]. Chin J Mod Drug Appl 2017; 11(6): 75-77.
  29. Panek M, Pietras T, Fabijan A et al. Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes. Experimental and therapeutic medicine 2013; 5(2): 572-580.
  30. Panek M, Pietras T, Antczak A, Górski P, Kuna P, Szemraj J. The role of functional single nucleotide polymorphisms of the human glucocorticoid receptor gene NR3C1 in Polish patients with bronchial asthma. Molecular biology reports 2012; 39(4): 4749.
  31. Panek M, Jonakowski M, Zioło J et al. A novel approach to understanding the role of polymorphic forms of the NR3C1 and TGF-β1 genes in the modulation of the expression of IL-5 and IL-15 mRNA in asthmatic inflammation. Molecular medicine reports 2016; 13(6).
  32. Zhao F, Zhou G, Ouyang H et al. Association of the glucocorticoid receptor D641V variant with steroid-resistant asthma: a case-control study. Pharmacogenetics and genomics 2015; 25(6).
  33. Panek M, Pietras T, Antczak A et al. The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma. International journal of molecular medicine 2012; 30(1): 142-150.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 778 Download : 416