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Vol. 66 No. 1: Issue 1

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Protective effect of Specnuezhenide on islet β cell of rats with gestational diabetes mellitus

https://doi.org/10.14715/cmb/2019.66.1.10
Jing Yang
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, PR China
Jian Jia
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, PR China
Yongkang Yang
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, PR China
Yaning Zhao
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, PR China
Qin Li
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, PR China

Corresponding Author(s) : Yongkang Yang

krsgm9@163.com

Cellular and Molecular Biology, Vol. 66 No. 1: Issue 1

Abstract

Gestational diabetes mellitus (GDM) refers to diabetes mellitus and impaired glucose tolerance first diagnosed during pregnancy without previous history of the disease. Usually, GDM has a high risk of inducing type 2 diabetes mellitus. The incidence of GDM is increasing year by year worldwide, and it seriously affects the quality of life of patients, and increases the risk to pregnancy. Specnuezhenide (SPZ) is a characteristic active component of Ligustrum lucidum, a plant which exerts a variety of pharmacological effects. In this study, the protective effect of SPZ on β cells in gestational diabetes mellitus rats was investigated in a rat model of gestational diabetes. Based on oral glucose tolerance test, ELISA, qRT-PCR and western blotting assays, It was found that SPZ effectively improved blood sugar control and glucose tolerance in gestational diabetic rats, inhibited inflammation in islet tissue, and reduced inflammation-mediated insulin resistance.

Keywords

Specnuezhenide Proliferation Apoptosis Inflammation Chondrocytes.
Yang, J., Jia, J., Yang, Y., Zhao, Y., & Li, Q. (2020). Protective effect of Specnuezhenide on islet β cell of rats with gestational diabetes mellitus. Cellular and Molecular Biology, 66(1), 60–64. https://doi.org/10.14715/cmb/2019.66.1.10
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References
  1. Ruohomäki A, Toffol E, Upadhyaya S, Keski-Nisula L, Pekkanen J, Lampi J, et al. The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study. J Affect Disord 2018; 241: 263-268.
  2. Kamana K, Shakya S, Zhang H. Gestational diabetes mellitus and macrosomia: a literature review. Ann Nutr Metab 2015; 66: 14-20.
  3. Wang YH, Wu HH, Ding H, Li Y, Wang ZH, Li F, et al. Changes of insulin resistance and β-cell function in women with gestational diabetes mellitus and normal pregnant women during mid-and late pregnant period: A case–control study. J Obstet Gynaecol Res 2013; 39: 647-652.
  4. Dong J, Zhang J. Advances in the research of iridoids occurring in plants. J Northwest Forestry College 2004; 19: 131-135.
  5. Guo N, Yu Y, Ablajan K, Li L, Fan B, Peng J, et al. Seasonal variations in metabolite profiling of the fruits of Ligustrum lucidum Ait. Rapid Commun Mass Spectrom 2011; 25: 1701-1714.
  6. Wu J, Ke X, Fu W, Gao X, Zhang H, Wang W, et al. Inhibition of hypoxia-induced retinal angiogenesis by specnuezhenide, an effective constituent of Ligustrum lucidum Ait., through suppression of the HIF-1α/VEGF signaling pathway. Molecules 2016; 21: 1756.
  7. John C, Ramasamy R, Al Naqeeb G, Al-Nuaimi A, Adam A. Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses. Curr Med Chem 2012; 19: 5181-5186.
  8. Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, et al. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice. PloS one 2013; 8: 66744.
  9. Gilbert L, Gross J, Lanzi S, Quansah DY, Puder J, Horsch A. How diet, physical activity and psychosocial well-being interact in women with gestational diabetes mellitus: an integrative review. BMC Pregnancy Childbirth 2019; 19: 60.
  10. Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, et al. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nature Med 2001; 7: 1133.
  11. Singh BN, Kumar D, Shankar S, Srivastava RK. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochem Pharmacol 2012; 84: 1154-1163.
  12. Thomann R, Rossinelli N, Keller U, Tirri BF, De Geyter C, Ruiz J, et al. Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome. Gynecol Endocrinol 2008; 24: 199-206.
  13. Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, et al. Reduced skeletal muscle inhibitor of κBβ content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes 2006; 55: 760-767.
  14. Lee EJ, Duan WR, Kotlar T, Jameson JL. Restoration of growth hormone-releasing hormone (GHRH) responsiveness in pituitary GH3 cells by adenovirus-directed expression of the human GHRH receptor. Endocrinology 2001; 142: 414-420.
  15. Wang S, Yang Z, Xiong F, Chen C, Chao X, Huang J, et al. Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway. Mol Cell Endocrinol 2016; 434: 135-143.
  16. Maria Elizabeth MP, Clara OC, Del Carmen M. Pancreatic β-cells and type 2 diabetes development. Curr Diabetes Rev 2017; 13: 108-121.
  17. Raleigh D, Zhang X, Hastoy B, Clark A. The β-cell assassin: IAPP cytotoxicity. J Mol Endocrinol 2017; 59: 121-140.
  18. Kupsal K, Mudigonda S, Gundapaneni KK, Tupurani MA, Galimudi RK, Nyayapathi VS. Glucotoxicity and lipotoxicity induced beta-cell apoptosis in type 2 diabetes mellitus. Int J Anal Bio-Sci Vol 2015; 3: 4.
  19. Ghasemian M, Mahdavi M, Zare P, Feizi MAH. Spiroquinazolinone-induced cytotoxicity and apoptosis in K562 human leukemia cells: alteration in expression levels of Bcl-2 and Bax. J Toxicol Sci 2015; 40: 115-126.
  20. Mañas A, Wang S, Nelson A, Li J, Zhao Y, Zhang H, et al. The functional domains for Bax∆ 2 aggregate-mediated caspase 8-dependent cell death. Exp Cell Res 2017; 359: 342-355.
  21. Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, et al. PCSK9 promotes oxLDL-induced PC12 cell apoptosis through the Bcl-2/Bax-Caspase 9/3 signaling pathway. J Alzheimers Dis 2017; 57: 723-734.
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