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Vol. 66 No. 3: Issue 3

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Correlation of serum BNP and ET-1 levels with cardiac pump function and ventricular remodeling in patients with heart failure

https://doi.org/10.14715/cmb/2020.66.3.19
Limin Qin
Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang 261031, China
Xiaohong Liu
Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang 261031, China
Yi Li
Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang 261031, China

Corresponding Author(s) : Yi Li

yili126@mail.ru

Cellular and Molecular Biology, Vol. 66 No. 3: Issue 3

Abstract

This study aimed to explore the correlation of serum brain natriuretic peptide (BNP) and endothelin-1 (ET-1) levels with cardiac pump function and ventricular remodeling in patients with heart failure. Eighty-one patients with chronic heart failure admitted to our hospital from March 2016 to November 2018 were enrolled as the study group, and 80 healthy individuals as the control group. Immunofluorescence was used for the detection of serum BNP, ELISA for serum ET-1, and ultrasound for related indexes of cardiac pump function and ventricular remodeling. Moreover, correlation analysis and prognostic factors analysis were carried out. Both BNP and ET-1 were highly expressed in the serum of patients with heart failure. Cardiac pump function related indexes (left atrial ejection fraction (LAEF), left atrial passive ejection fraction (LAPEF), and left atrial active ejection fraction (LAAEF)) in the study group were significantly lower than those in the control group (P< 0.05). While ventricular remodeling related indexes (left ventricular end-diastolic diameter (LVEDD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPM), and left ventricular mass index (LVMI) in the study group were significantly higher than those in the control group (P< 0.05). BNP and ET-1 were negatively correlated with LAEF, LAPEF and LAAEF (P< 0.05), and were positively correlated with LVEDD, IVST, LVPM and LVMI (P< 0.05). The expressions of serum BNP and ET-1 were higher in patients with cardiovascular events than those without cardiovascular events. Hypertension, hyponatremia, high BNP, high ET-1, NYHA classification, decreased LAEF and increased LVEDD were independent risk factors for cardiovascular adverse events. Serum BNP and ET-1 are closely related to cardiac pump function and ventricular remodeling in patients with heart failure and can be used as important reference indexes for prognosis evaluation.

Keywords

Heart failure BNP ET-1 Cardiac pump function Ventricular remodeling Correlation.
Qin, L., Liu, X., & Li, Y. (2020). Correlation of serum BNP and ET-1 levels with cardiac pump function and ventricular remodeling in patients with heart failure. Cellular and Molecular Biology, 66(3), 125–131. https://doi.org/10.14715/cmb/2020.66.3.19
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References
  1. Testa G, Cacciatore F, Bianco A, Della-Morte D, Mazzella F, Galizia G, Gargiulo G, Curcio F, Liguori I, Sabusco A, Rengo F. Chronic obstructive pulmonary disease and long-term mortality in elderly subjects with chronic heart failure. Aging Clin Exp Res 2017; 29: 1157-1164.
  2. Meijers W C, Velde A R V D, Kobold A C M, Dijck-Brouwer J, Wu AH, Jaffe A, de Boer RA. Variability of biomarkers in patients with chronic heart failure and healthy controls. Eur J Heart Fail 2017; 19: 357-365.
  3. Jorsal A, Kistorp C, Holmager P, Tougaard RS, Nielsen R, Hänselmann A, Nilsson B, Mí¸ller JE, Hjort J, Rasmussen J, Boesgaard TW. Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)-a multicentre, double-blind, randomised, placebo-controlled trial. Eur J Heart Fail 2017; 19: 69-77.
  4. Sutton MSJ, Linde C, Gold M R, Abraham WT, Ghio S, Cerkvenik J, Daubert JC, REVERSE Study Group. Left Ventricular Architecture, Long-Term Reverse Remodeling, and Clinical Outcome in Mild Heart Failure With CardiacResynchronization: Results From the REVERSE Trial. Jacc Heart Fail 2017; 5: 169-178.
  5. Lottonen-Raikaslehto L, Rissanen R, Gurzeler E, Merentie M, Huusko J, Schneider JE, Liimatainen T, Ylä-Herttuala S. Left ventricular remodeling leads to heart failure in mice with cardiac"specific overexpression of VEGF"B167: echocardiography and magnetic resonance imaging study. Physiol Rep 2017; 5: e13096.
  6. Lucas CM. Stiff left atrial syndrome as another cause for heart failure with preserved ejection fraction and normal BNP levels. Neth Heart 2017; 25: 224.
  7. Kitada S, Kikuchi S, Tsujino T, Masuyama T, Ohte N, J-MELODIC study investigators. The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub- analysis of the J-MELODIC study. Esc Heart Fail 2017; 5: 36-45.
  8. Zhang X, Cheng H J, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP. Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Int J Cardiol 2017; 236: 405-412.
  9. Platt M J, Huber J S, Romanova N, Brunt KR, Simpson JA. Pathophysiological Mapping of Experimental Heart Failure: Left and Right Ventricular Remodeling in Transverse Aortic Constriction Is Temporally, Kinetically and Structurally Distinct. Front Physiol 2018; 9: 472.
  10. Peng T, Li X, Hu Z, Yang X, Ma C. Predictive role of endothelin in left ventricular remodeling of chronic kidney disease. Ren Fail 2018; 40: 183-186.
  11. Bosch L, Csp L, Gong L, Chan SP, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM. Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. Eur J Heart Fail 2017; 19: 1664-1671.
  12. Von R M, Rommel K P, Kowallick J T, Blazek S, Besler C, Fengler K, Lotz J, HasenfuíŸ G, Lücke C, Gutberlet M, Schuler G. Influence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction. Circ Cardiovasc Imaging 2017; 10: e005467.
  13. Aronow WS. Treatment of Heart Failure with Abnormal Left Ventricular Systolic Function in Older Adults. Heart Fail Clin 2017; 13: 467-483.
  14. Khalid U, Wruck L M, Quibrera P M, Bozkurt B, Nambi V, Virani SS, Jneid H, Agarwal S, Chang PP, Loehr L, Basra SS. BNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: The Atherosclerosis Risk in Communities Surveillance Study. Int J Cardiol 2017; 233: 61-66.
  15. Dzudie A, Dzekem BS, Kengne AP. NT-pro BNP and plasma-soluble ST2 as promising biomarkers for hypertension, hypertensive heart disease and heart failure in sub-Saharan Africa. Cardiovasc J Afr 2017; 28: 406-407.
  16. McMurray JJ, Adamopoulos S, Anker SD. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure2012:The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012of the European Society of Cardiology Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012; 14: 803-869.
  17. Xu W, Tao H, Hu D, Wang G. Serum BNP level expression of child patients suffering from ventricular septal defects of CHD and its relation with cardiac function and heart failure. Minerva Pediatr 2017.
  18. Zhang C L, Xie S, Qiao X, An YM, Zhang Y, Li L, Guo XB, Zhang FC, Wu LL. Plasma endothelin-1-related peptides as the prognostic biomarkers for heart failure: A PRISMA-compliant meta-analysis. Medicine 2017; 96: e9342.
  19. Karmazyn M. Chapter 3 – Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease. Endocrinology of the Heart in Health & Disease 2017; pp: 59-85.
  20. Udelson JE, Konstam MA. Ventricular remodeling fundamental to the progression (and regression) of heart failure. J Am Coll Cardiol 2011; 57: 1477- 479.
  21. He Q, Huang Y. Correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure. J Hainan Med Univ (English Edition) 2017; 23(2): 65-9.
  22. Huang Y, Qiu J, Lu J, Lei H, Wei M, Qiu G. Changes of plasma nt-probnp and MMP-2 levels and relationship with left ventricular remodeling in patients treated by pravastatin with chf after PCI therapy for AMI. J Shanghai Jiaotong Univ (Med Sci) 2010; 30(3):336-9.
  23. Liang Y, Lin Q, Huang P, Wang Y, Li J, Zhang L, Cao J. Rice Bioactive Peptide Binding with TLR4 To Overcome H2O2-Induced Injury in Human Umbilical Vein Endothelial Cells through NF-κB Signaling. J Agri Food Chem 2018; 66(2): 440-448.
  24. Wang L, Lin Q, Yang T, Liang Y, Nie Y, Luo Y, Luo F. Oryzanol modifies high fat diet-induced obesity, liver gene expression profile, and inflammation response in mice. J Agri Food Chem 2017; 65(38): 8374-8385.
  25. Lou Y, Shi J, Guo D, Qureshi AK, Song L. Function of PD-L1 in antitumor immunity of glioma cells. Saudi J Boil Sci 2017; 24(4): 803-807.
  26. Guo T, Lin Q, Li X, Nie Y, Wang L, Shi L, Luo F. Octacosanol attenuates inflammation in both RAW264. 7 macrophages and a mouse model of colitis. J Agri Food Chem 2017; 65(18): 3647-3658.
  27. Li W, Jia MX, Wang JH, Lu JL, Deng J, Tang JX, Liu C. Association of MMP9-1562C/T and MMP13-77A/G polymorphisms with non-small cell lung cancer in southern Chinese population. Biomol 2019; 9(3): 107-119.
  28. Nie Y, Luo F, Wang L, Yang T, Shi L, Li X, Shen J, Xu W, Guo T, Lin Q. Anti-hyperlipidemic effect of rice bran polysaccharide and its potential mechanism in high-fat diet mice. Food Func 2017; 8(11): 4028-4041.
  29. Lou Y, Yang J, Wang L, Chen X, Xin X, Liu Y. The clinical efficacy study of treatment to Chiari malformation type I with syringomyelia under the minimally invasive surgery of resection of Submeningeal cerebellar Tonsillar Herniation and reconstruction of Cisterna magna. Saudi J Biol Sci 2019; 26(8): 1927-1931.
  30. Lou Y, Guo D, Zhang H, Song L. Effectiveness of mesenchymal stems cells cultured by hanging drop vs. conventional culturing on the repair of hypoxic-ischemic-damaged mouse brains, measured by stemness gene expression. Open Life Sci 2016; 11(1): 519-523.
  31. Chen X, Xu Y, Meng L, Chen X, Yuan L, Cai Q, Shi W, Huang G. Non-parametric partial least squares–discriminant analysis model based on sum of ranking difference algorithm for tea grade identification using electronic tongue data identify tea grade using e-tongue data. Sens Actuators B Chem 2020; 127924.
  32. Nie Y, Luo F, Lin Q. Dietary nutrition and gut microflora: A promising target for treating diseases. Trends Food Sci Technol 2018;75: 72-80.
  33. Ren Y, Jiao X, Zhang L. Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance. Saudi J Biol Sci 2018; 25(3): 469-473.
  34. Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J, NICE Guideline Development Group for Acute Heart Failure. The diagnostic accuracy of the natriuretic peptides in heart failure:systematic review and diagnostic meta-analysis in the acute care setting. BMJ 2015; 350: h910.
  35. Balion C, McKelvie R, Don-Wauchope AC, Santaguida PL, Oremus M, Keshavarz H, Hill SA, Booth RA, Ali U, Brown JA, Bustamam A. B-type natriuretic peptide-guided therapy:a systematic review. Heart Fail Rev 2014; 19: 553-564.
  36. Baldasseroni S, Urso R, Orso F, Bianchini BP, Carbonieri E, Cirò A, Gonzini L, Leonardi G, Marchionni N, Maggioni AP. Relation between serum sodium levels and prognosis in outpatients with chronic heart failure:neutral effect of treatment with beta-blockers an angiotensin-converting enzyme inhibitors:data from the Italian Network on Congestive Heart Failure (IN-CHF database). J Cardiovasc Med (Hagerstown) 2011; 12: 723-731.
  37. Badran H A, Abdelhamid M A, Ibrahim M T, Abdelmoteleb AM, Zarif JK. Left atrium in cardiac resynchronization therapy: Active participant or innocent bystander. J Saudi Heart Assoc 2017; 29: 259-269.
  38. Li J, Tang B, Zhang W, Wang C, Yang S, Zhang B, Gao X. Relationship and mechanism of Kv2.1 expression to ADH secretion in rats with heart failure. Am J Transl Res 2017; 9: 3687-3695.
  39. Kim S H, Kim H J, Han S, Yoo BS, Choi DJ, Kim JJ, Jeon ES, Cho MC, Chae SC, Ryu KH. The limited prognostic role of echocardiograms in short-term follow-up after acute decompensated heart failure: An analysis of the Korean Heart Failure (KorHF) Registry. Plos One 2017; 12: e0188938.
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