Copyright (c) 2023 Guiying Wang, Lilin Luo
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Detection of circulating tumor cells in patients with pancreatic cancer by novel nano microfluidic chips and comprehensive nursing intervention
Corresponding Author(s) : Lilin Luo
Cellular and Molecular Biology,
Vol. 69 No. 14: Cancer molecular biology: Diagnosis and treatment
Abstract
It was to explore the detection efficiency of novel nano microfluidic chips on circulating tumor cells (CTCs) in pancreatic cancer (PC) patients and the effect of comprehensive nursing intervention on the life indicators of patients after PC surgery. PC, benign pancreas, and healthy volunteers were enrolled. The number and positive rate of CTCs in the subjects, the relationship between the number of CTCs in PC patients and clinical data, the recurrence rate, and the life indicators of patients after intervention were sorted out and analyzed. The positive rate of CTCs was 96.67% in PC group (29/30), 16.67% in benign pancreas group (5/30), and 0% in healthy controls. The positive CTCs in PC patients were correlated with vascular invasion (P<0.05). The recurrence rate after PC resection was 56.67% (17/30). The positive detection rate of nano microfluidic chip was 30/30 (100%), which was higher than against CellSeach 7/30 (23.33%), P<0.05. The physiological function score of intervention group (93.67±1.48) was higher as against controls (60.45±2.03), P<0.05. The social function score of intervention group (91.26±0.44) was higher as against controls (54.92±2.98), P<0.05. The novel nano microfluidic chip has high sensitivity and specificity for the detection of CTCs in PC patients. Postoperative comprehensive nursing intervention can improve the quality of life (QoL) and functional status of PC patients.
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