Liyan  Zou; Duosheng  Zhu; Min  Gong; Jiangyi Yu

doi:10.14715/cmb/2024.70.3.25

Issue

Vol. 70 No. 3: Issue 3

Issue Published : April 29, 2024

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

The influence of genetic predisposition to oxidative stress on painful diabetic peripheral neuropathy: A mendelian randomization study

Genetic oxidative stress impact on diabetic neuropathy pain

https://doi.org/10.14715/cmb/2024.70.3.25

Liyan Zou

Nanjing University of Chinese Medicine, Nanjing 210000, China

Duosheng Zhu

Department of Endocrinology and Nephrology, Jiaozhou Traditional Chinese Medicine Hospital, Jiaozhou 266300, China

Min Gong

Department of Endocrinology, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao 266033, China

Jiangyi Yu

Department of Endocrinology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, the First Clinical Medical College, Nanjing 210029, China

Corresponding Author(s) : Jiangyi Yu

zly_198724@126.com

Cellular and Molecular Biology, Vol. 70 No. 3: Issue 3
Article Published : March 31, 2024

Abstract

Genetic predisposition to oxidative stress (OS) may influence the risk of Painful Diabetic Peripheral Neuropathy (PDPN). This study employed a Mendelian Randomization (MR) approach to investigate the causal relationship between genetic predisposition to OS and PDPN. Genetic instruments associated with OS biomarkers were selected as exposures. Summary-level data on PDPN was obtained from the largest available genome-wide association study (GWAS). MR analyses were conducted using the inverse-variance weighted (IVW) method, with sensitivity analyses employing the MR-Egger, weighted median, and MR-PRESSO approaches. Genetic predisposition to increased glutathione S-transferase (GST) activity was associated with a reduced risk of PDPN (OR=0.66, 95%CI: 0.49-0.89, P=0.006). Higher ascorbate levels conferred a protective effect against PDPN (OR=0.83, 95%CI: 0.71-0.97, P=0.018). No significant association was observed between genetic predisposition to OS biomarkers and PDPN severity. Genetic predisposition to increased GST activity and higher ascorbate levels protect against the development of PDPN, suggesting a causal relationship.

Keywords

Oxidative Stress (OS) Painful Diabetic Peripheral Neuropathy (PDPN) Mendelian Randomization (MR)

Zou, L. ., Zhu, D. ., Gong, M. ., & Yu, J. (2024). The influence of genetic predisposition to oxidative stress on painful diabetic peripheral neuropathy: A mendelian randomization study: Genetic oxidative stress impact on diabetic neuropathy pain. Cellular and Molecular Biology, 70(3), 168–173. https://doi.org/10.14715/cmb/2024.70.3.25