Published: February 4, 2022

Original Research Articles

Computational molecular characterization of p53 and Human TLRs interactions

February 4, 2022
1-5
Mohammad JahoorAlam, Fevzi Bardakci, Sadia Anjum, Shumayla Rasheed Mir, Irfan Ahmad, Mohd Saeed

Therapeutic potential of Ceratonia siliqua extract for the management of asthma and hypertension

February 4, 2022
6-15
Irfan Hamid, Khalid Hussain Janbaz, Rabia Iqbal, Muhammad Furqan Akhtar, Ammara Saleem, Sajid Ali, Ali Sharif, Bushra Akhtar, Zeeshan Javaid, Kashif Sohail

Identifying the alpha-glucosidase inhibitory potential of dietary phytochemicals against diabetes mellitus type 2 via molecular interactions and dynamics simulation

February 4, 2022
16-26
Mohd Adnan Kausar, SMA Shahid, Sadaf Anwar, M Kuddus, Mohammad Kalim Ahmad Khan, Amany Mohammed Khalifa, Fahmida Khatoon, Abdullah D. Alotaibi, Salman F. Alkhodairy, Mejdi Snoussi, Jamal M. Arif

Contemporary uses of old folks: the immunomodulatory and toxic potential of fenbufen

February 4, 2022
27-37
Muhammad Furqan Akhtar, Mehr-un- Nisa, Ammara Saleem, Irfan Hamid, Khalaf F. Alsharif, Mohamed M. Abdel-Daim, Md. Habibur Rahman, Muddaser Shah, Kashif Sohail, Zeeshan Javaid

BAG2-activated cell autophagy and mir-27b dynamic regulation mechanism during Mycobacterium tuberculosis infection

February 4, 2022
38-44
Xiaoming Xing, Cuiyun Zhang, Jie Zhou, Qian Jin, Qinfang Zheng

Changes in inflammatory factors, oxidative stress, glucose and lipid metabolism, and insulin resistance in patients with polycystic ovary syndrome

February 4, 2022
45-50
Peiwen Zhong, Baoxing Guan, Yanting Lin, Siyou Zhang

Circulating tumor DNA detection in peripheral blood in postoperative efficacy evaluation and recurrence risk prediction of lung cancer

February 4, 2022
51-56
Kun Lv, Xiongtiao Yang, Zhihua Li, Chengfang Ma, Qiongchuan Hong

Expression of Serum PSA, Nesfatin-1, and AMH in Patients with Polycystic Ovary Syndrome

February 4, 2022
57-63
Yan Wang, Xiaorong Ma, Jiashou Luo, Xiaoyan Wang, Lu Han

Fasudil on Myocardial Injury in Rats with Myocardial Ischemia and Reperfusion through Rho-ROCK Signal Pathway

February 4, 2022
64-72
Zhiyun Zhu, Bo Qiu, Qiang Wang, Wei Wei, Jinlong Huang, Wenfen Duan

Ibuprofen on Proliferation and Apoptosis of Sarcoma Cells via PI3K/Akt/mTOR Signaling Pathway

February 4, 2022
Ye Bai, Ning Guo, Qinghe Chen, Yuxi Chen, Zhenggang Bi

MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1

February 4, 2022
81-87
Na Wen, Ji Zhang, Qiaoyu Zhang

Molecular Mechanism of Integrin αvβ6 in Liver Metastasis of Colon Cancer Based on SDF-1/CXCR4

February 4, 2022
88-95
Jinglong Shi, Ludi Fan, Bo Li, Hui Pan

Remifentanil Anesthesia on the Expression of Apoptosis-Related Proteins Bcl-2 and Bax in Rat Myocardial Cells with Ischemia-Reperfusion Injury

February 4, 2022
96-103
Jie Li, Shuguang Wang, Shaoyan Huang, Wei Shao, Jianzhong Zhang

Clinical significance of detection of mononuclear phagocyte subsets in blood and bronchoalveolar lavage fluid (BALF) in pulmonary sarcoidosis

February 4, 2022
109-116
Hong Qiaozhen, Zhang Jifei, He Lingrong, Yu Qiuming, Yu Hongjuan, Hong Qiaozhen

Small molecule TKI inhibitors affect the development of non-small cell carcinoma through HIPPO/YAP/PD-L1

February 4, 2022
117-122
Li Lei, Zhang Weidong

MiR-182 antagonist alleviates glucocorticoid-induced secondary bone degeneration and osteoclast differentiation

February 4, 2022
123-130
Bin Zhao, Min Luo, Aiyuan Wang, Weili Zhang

The regulating role of miR-494 on HCCR1 in cervical cancer cells

February 4, 2022
131-137
Ziwen Zheng, Xiaorong Yang, Qinde Yu, Ling Li, Li Qiao

Re-positive PCR of SARS-CoV-2 in health care persons during COVID-19 pandemic

February 4, 2022
138-143
Masoud Alebouyeh, Pooya Aavani, Nareen Arif Abdulrahman, Azad Abduljabar Haleem, Abdollah Karimi, Shahnaz Armin, Fatemeh Fallah, Arezu Amirali, Saeed Sadr, Ghazaleh Ghandchi, Nafiseh Abdollahi, Roxana Mansour Ghanaie, Sedigheh Rafiei Tabatabaei, Seyed Alireza Fahimzad, Raheleh Razmara, Khalid J. Alzahrani, Ghamartaj Khanbabaee, Soheila Sadat Vaghefi, Farid Imanzadeh, Peyman Eshghi, Leila Azimi

Effects of imbalance of lipid metabolism through NF-KB pathway on atherosclerosis and vascular aging in rats

February 4, 2022
144-150
Xiangyong Kong, Hongwu Chen, Dan Li, Likun Ma

Correlation between CYP2C9 gene polymorphism and warfarin dose in Chinese Han population with coronary heart disease

December 15, 2021
157-163
Qiyu Zuo, Li Li, Mingjing Zhong, Gengbiao Chen, Junhui Xio

The mechanism of Danzikang Knee Granule in regulating the chondrogenic differentiation of mesenchymal stem cells based on TGF-β signaling pathway in cartilage repair in knee osteoarthritis

February 4, 2022
164-173
Yu Xiaoyu, Xiong Hui, Lu Xiaolong, Xiang Lili, Yang Zhuo, Qi Xinyu

Comparative study on sex hormone secretion in peripheral blood of women with common hematological tumors before and after chemotherapy

February 4, 2022
174-180
Liying Liu, Kexin Zhou, Liping Yao, Rui Hou, Hui Zhu

The effect of locating and sliding of facet combined with percutaneous endoscopic lumbar discectomy on cell inflammatory indicators and the treatment of disc herniation

February 4, 2022
181-187
Qingshan Zhang, Peijin Du, Yaning Zhang

The role of IL-6, IL-10, and PGE2 in the treatment of intervertebral disc herniation by dual-channel endoscopic lumbar discectomy

February 4, 2022
188-195
Peijin Du, Qingshan Zhang, Yaning Zhang

miR-129-5p Plays an Anticancer Role in Colon Cancer by Targeting RSF1

February 4, 2022
196-201
Junfeng Hao, Hongxia Wei, Yabin Qi, Haiwang Liu

The Therapeutic Effect of miRNA-19a/19b on Heart Failure in Mice and the Mechanism of Myocardial Regeneration and Repair

February 4, 2022
202-209
Lei Jin

Effects of endoplasmic reticulum stress, liver function, insulin resistance and vascular endothelial function in patients with nonalcoholic fatty liver disease

February 4, 2022
210-217
Yong Zheng, Hongning Shi, Yahao Zhou, Ayong Wang, Dufu Kang, Limin Kang

Significance of screening sensitive methylation sites using whole-genome sequencing in early diagnosis of non-small cell lung cancer

February 4, 2022
218-226
Yu Zhang, Ning Lu, Shunchang Pu, Kui Mu

The relationship between serum vitamin D level with inflammatory markers and Total Antioxidant Capacity in Oral lichen planus

February 4, 2022
227-232
Yuhan Hu

Evaluation of CK19 and VEGF gene expression, ki67 antigen, p53 protein, C-erb-B2, and their relationship in oral squamous cell carcinoma

February 4, 2022
233-239
Yuchen Shen, Zhongqiang Xu, Miaomiao Liu, Songlin Piao, Jichen Li

Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure

February 4, 2022
240-247
He Jie, Wang Jinxiang, Li Ye, Zhao Jing, Zhu X iangqing, Hu Jinxiu, Li Zian, Pan Xinghua

Expression of LncRNA-BCYRN1 in pediatric asthma and related factors of disease induction

February 4, 2022
248-255
Xufeng Huang, Zhengguo Huang, Chengliang Shao, Bin Zheng, Jing Zhang

MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells Through FGF1

February 4, 2022
256-262
Dewen Wang, Chunying Wang, Lei Sun, Xiang Lu, Jiangwei Shi, Jing Chen, Xuesong Zhang

Efficacy and safety of transarterial infusion of anti-PD-1 in the treatment of advanced or metastatic acral and mucosal melanomas

February 4, 2022
263-268
Chen Qianqi, Zhao Yan, Tang Yueqiang, Duan Jiangman, Fu Xiaohong, Zhou Qiming

The Effect of Interleukin-6 and Tumor Necrosis Factor-Alpha Gene Polymorphism and Hormone Replacement Therapy on Polycystic Ovary Syndrome

February 4, 2022
278-285
Sarhang Hasan Azeez, Ismail Bilal Ismail, Suhaila Nafia Darogha

Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

February 4, 2022
286-292
Sun Min, Liu Xiaxing, Bai Yu, An Yinghua, Li Yaoni, Wang Jinbo

Changes of serum miR-221 and miR-145 levels with papillary thyroid carcinoma and their relationship with invasive activity

February 4, 2022
293-301
Zheng-Cai Zhu, Tao Li, Tian-Qi Yao, Jing-Cheng Bi, Liang-He Jiao

Analysis of levels and Clinical value of CA19-9, NLR and SIRI in patients with Pancreatic Cancer with different Clinical Features

February 4, 2022
302-308
Li Min, Dong Ziyu, Zhang Xiaofei, Xue Shunhe, Wang Bolin

Effect of ultra-mini percutaneous nephrolithotomy and ShuoTong ureteroscopy on the stress response, inflammatory indices, and urokinase level in patients with polycystic kidney disease complicated with renal calculus

February 4, 2022
309-316
Du Qiao, Luo Cheng, Tian Xiaomei, Shi Baolei, Li Yingyi, Zhang Hui, Bian Shaohua, Liu Wei, Dai Y u, Deng Fangqiong, Liu Jie, Liu Shuangning

Effect of Tiaojingzhixue Fang on the expression of sex hormone and endometrial tissue mRNA in perimenopausal patients with abnormal uterine bleeding

February 4, 2022
317-323
Leilei Guan, Lili Xue, Jingping Chu, Jianfang Xue, Shuhua Zhang, Ling Zhu

Clinical Significance of MiR-27a Expression in Serum Exosomes in Patients with Heart Failure

February 4, 2022
324-331
Yuetao Xie, Jinli Z hang, Ning Zhang, Guang Liu

The affection of plasma exosomes on airway obstruction and endothelial function in OSA patients

February 4, 2022
332-339
Lin Li, Qing Wang, Wenshu Xin, Kaixue Wen, Yuhao Z hang

Possible Mechanism of Placental Mesenchymal Stem Cell-Derived Neural Cell Transplantation on the Recovery of Neurogenic Bladder Function after Spinal Cord Injury

February 4, 2022
340-347
Ming Yao, Guo Liu, Yourui Li, Hualei Song

Propofol Regulates the Expression of BecliN-1 through miR-30b and Protects against Lung Ischemia-Reperfusion Injury

February 4, 2022
348-355
Huanju Kang, Junjie Chen, Su Cao

Effects of mFOLFOX6 regimen combined with carrelizumab on immune function and prognosis in patients with microsatellite instability colorectal cancer

February 4, 2022
356-362
Jie Sun, Ninghua Yao, Pengpeng Lu, Yan Wang

Clinical features, treatment, and prognosis of 16 breast cancer patients with ocular metastases

February 4, 2022
363-370
Chunxiao Chang, Yuhong Shang, Yongsheng Gao, Mao Shang, Lizheng Wang, Huihui Li

Comparative Computational Analysis of Dirithromycin and Azithromycin in Search for a Potent Drug against COVID-19 caused by SARS-CoV-2: Evidence from molecular docking and dynamic simulation

February 4, 2022
371-386
Kadri Adel, Mosbah Amor, Redissi Alaeddine, Noumi Emira, Alreshidi Mousa, Aouadi Kaïss, Ghannay Siwar, Siddiqui Arif Jamal, Adnan Mohd, Vincenzo De Feo, Snoussi Mejdi

Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches

February 4, 2022
387-398
Rafat Zrieq, Mejdi Snoussi, Fahad D. Algahtan, Munazzah Tasleem, Mohd Saeed, Emira Noumi, Nasrin E. Khalifa, Mohamed A. M. Gad-Elkareem, Kaïss Aouadi, Adel Kadri

Comparison of Her-2/Neu Gene Amplification or Expression between IHC and FISH in BC

February 4, 2022
399-404
Qinqin Zhang, Lei Jin, Hua Gong

Identification of differentially expressed genes, transcription factors, microRNAs and pathways in neutrophils of sepsis patients through bioinformatics analysis

February 4, 2022
405-420
Yukai Zheng, Lu Peng, Zhijie He, Zijun Zou, Fangyi Li, Canxia Huang, Weichao Li

The relationship between different interleukins and T helper cells count in patients with immune thrombocytopenia

February 4, 2022
421-426
Yuru Li, Chuandong Hou, Wenjing Yan, Xiaoxia Li, Xinli Deng

A systematic analysis of molecular mechanisms in non-metastatic renal cancer delineates affected regulatory pathways and genes in tumor growth

February 4, 2022
427-438
Rongjun Xia, Lijuan Lin, Shengjin Yu, Jinhui Zhang, Linlin Zheng, Lijie Zhou, Junrong Lin

Diclofenac biotransformation and toxicity assessment of laccase from Pleurotus floridanus

February 4, 2022
439-450
Dhrisya Chenthamara, Sankar Ganesh Ramakrishnan, Ameer Khusro, Sadhasivam Subramaniam, Saad Alghamdi, Mazen Almehmadi, Ahmed Kabrah, Muhammad Umar Khayam Sahibzada, Aziz Eftekhari

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

February 4, 2022
451-457
Ayca Tas, Emrullah Hayta, Ahmet Karadag, Cemile Zontul, Esma Ozmen, Süleyman Aydin, Yavuz Silig

Reviews

Nanoformulations of curcumin and quercetin with silver nanoparticles for inactivation of bacteria

February 4, 2022
151-156
Mehran Alavi, Nareen Arif Adulrahman, Azad Abduljabar Haleem, Ahmed Diyar Hussein Al-Râwanduzi, Ameer Khusro, Mohamed A Abdelgawad, Mohammed M. Ghoneim, Gaber El-Saber Batiha, Danial Kahrizi, Fleming Martinez, Niranjan Koirala

The effect of neonatal nursing care on clinical symptoms and intestinal flora of children with acute diarrhea

February 4, 2022
269-277
Linxue Wang

Case Report

Primary mediastinal seminoma with leiomyosarcoma: a rare case report

February 4, 2022
104-108
Yali Qi, Chi Dong, Wenjun Cui, Lijun Da, Enxi Li, Yating Liu, Feixue Song