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Copyright (c) 2022 Mohammed Abdulameer Farhan, Amal Feki, Intissar Kammoun, Malek Aroui, Abderraouf Hilali, Manel Naifar, Rim Kallel, Fatma Makni Ayadi, Tahia Boudawara, Choumous Kallel, Ahmed Hakim, Adil Abaed Hassoni, Ibtissem Ben Amara
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Hypocholesterolemic effects of a polysaccharide isolated from Balangu (Lallemantia royleana) seeds in Wistar rat fed on a cholesterol-containing diet
Corresponding Author(s) : Ibtissem Ben Amara
Cellular and Molecular Biology,
Vol. 68 No. 10: Issue 10
Abstract
The present study aimed to evaluate the antioxidant effects of polysaccharide (PS) isolated from Balangu Shirazi (Lallemantia royleana) seeds in vitro as well as on the hypercholesterolemic diet-induced liver and kidney injury in adult rats. PS was structurally characterized by Fourier-transformed infrared, which confirmed the presence of bands characteristic of polysaccharides. Functional properties of PS were investigated based on water solubility index, holding and emulsifying capacities. The antioxidant activities were confirmed by DPPH radical scavenging assays, reducing power and the chelating effect assay. The administration of PS to a hypercholesterolemic diet for 30 days in Wistar rats significantly improved the liver and kidney levels in malondialdehyde, advanced oxidation protein products, glutathione, superoxide dismutase, glutathione peroxidase and in vitamin C. The oxidative stress profile was confirmed by hematological and plasma biochemical parameters. In addition, histological alterations were significantly ameliorated in liver and kidney tissues. The study strengthens the hypothesis that the herbal polysaccharide can be used as a novel antioxidant and hypocholesterolemic compound against hyperlipidemia-induced atherosclerosis.
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