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Copyright (c) 2022 Sarah Mukheef, Malek Eleroui, Hussein O. M. Al-Dahmoshi , Ibtissem Ben Amara
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Prevalence of Some Group A Beta-Lactamase Genes among Uropathogenic Escherichia coli isolated from Women with Cystitis
Corresponding Author(s) : Sarah Abdulkareem Mukheef
Cellular and Molecular Biology,
Vol. 68 No. 10: Issue 10
Abstract
Urinary tract infection is a common infection associated with considerable societal cost and even increasing antibiotic resistance, which to some extent represents a challenging issue facing infection control. In this work, some group A Beta-lactamase genes blaTEM, bla SHV, bla CTX-M-1, bla CTX-M-2, bla CTX-M-9, bla CTX-M-25 among Uropathogenic Escherichia coli from women with cystitis have been detected. The results showed that 100 isolates of 611 urine samples belonged to Escherichia coli. Antibiotic susceptibility testing of 100 isolates to 14 antibiotics revealed that 63%, 58%, 36%, 27%, 14%, 6%, 4%, 30%, 26%, 4%, 16%, 2%, and 44% of the isolates were resistant to Ceftazidime, Cefotaxime, Piperacillin, Amoxicillin-clavulanate, Aztreonam, Piperacillin-tazobactam, Imipenem, Meropenem, Levofloxacin, Ciprofloxacin, Gentamicin, Amikacin, Nitrofurantoin, and Trimethoprome-sulfamethoxazole, respectively. The results revealed that 29% of isolates were multidrug resistant. In the current study, the results of molecular detection showed the predominance of ESBL genes in Escherichia coli isolates: blaTEM 98% followed by blaSHV 69%, and then, blaCTX-M-1 66%. blaCTX-M-9 only appeared in one isolate. Both blaCTX-M-2 and blaCTX-M-25 were not detected. The study concludes the high spreading of coexistence of more than one gene of Group A β-lactamase genes among uropathogenic Escherichia coli causes them to resist many antibiotics. This makes the treatment regimen unusual or hard to be achieved.
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