The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Attenuation of 1-Methyl-4-Phenyl-1, 2,3,6-Tetrahydropyridine induced nigrostriatal toxicity in mice by N-Acetyl Cysteine
Corresponding Author(s) : A. Sharma
Cellular and Molecular Biology,
Vol. 53 No. 1: Role of free radicals and antioxidants in health and disease - Volume 1
Abstract
The present study was designed to investigate the effects of N-acetyl cysteine (NAC), an antioxidant on 1-methyl 4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) induced neurotoxicity in the nigrostriatal dopaminergic system of mice. MPTP treatment caused 80% decrease of the dopamine levels in the striatum of C57BL/ 6J mice. A marked increase in the extent of lipid peroxidation, superoxide dismutase (SOD) and g-glutamyl transpeptidase (g-GTP) was seen, while a significant decrease in the levels of glutathione (GSH), total thiols and glutathione peroxidase (GPx) activity was observed in the substantia nigra pars compacta (SNpc) of MPTP treated animals. As compared to control animals, Co-administration of NAC with MPTP restored the depleted dopamine, GSH, total tissue thiol levels and GPx activity in SNpc of treated mice brain. Moreover, NAC treatment also provided protection against lipid peroxidation and superoxide dismutase activity. The results of present study suggested that NAC attenuates MPTP neurotoxicity in mice brain and this protection by the NAC might be contributing to the regeneration of GSH, a major antioxidant.
Keywords
1-methyl-4-phenyl 1
2
3
6 tetrahydropyridine (MPTP)
N-acetyl cysteine (NAC)
Parkinson's disease
oxidative stress
glutathione.
Sharma, A., Kaur, P., Kumar, V., & Gill, K. D. (2007). Attenuation of 1-Methyl-4-Phenyl-1, 2,3,6-Tetrahydropyridine induced nigrostriatal toxicity in mice by N-Acetyl Cysteine. Cellular and Molecular Biology, 53(1), 48–55. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/1104
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX