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Vol. 63 No. 10: Issue 10

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Metabolic and molecular responses to calcium soap of fish oil fed to ewes during peripartal period

https://doi.org/10.14715/cmb/2017.63.10.2
S. Sheibani
Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Tehran, Iran
A. Mohammadi-Sangcheshmeh
Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Tehran, Iran
A. A. Alamouti
Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Tehran, Iran
A. A. Khadem
Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Tehran, Iran
M. A. Norouzian
Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Tehran, Iran

Corresponding Author(s) : A. A. Khadem

khajenabi@gmail.com

Cellular and Molecular Biology, Vol. 63 No. 10: Issue 10

Abstract

It has been shown that n-3 long chain fatty acids (n-3 LCFA) are involved in energy/lipid metabolisms, reproductive parameters, and molecular regulations leading to maintained homeostasis. We hypothesized that supplementation of peripartal diets with fish oil (FO), as a source of n-3 LCFA, could improve energy balance and modulate metabolic pressure in a sheep model. Prepartum ewes (n = 24) were fed control (CON) or  calcium soap of fish oil (FO) supplemented-diet from four weeks before until three weeks after parturation. Feed intake, body weight (BW) change, plasma metabolites, colostrums/milk composition, and fatty acids profile of milk along with the expression of core microRNAs in glucose and lipid metabolism were evaluated. Prepartal feed intake decreased in FO group (1674 ± 33.26 vs. 1812 ± 35.56) though post-partal intake was similar. Differences in BW were not also significant (55.47 ± 2.07 in CON vs. 53.69 ± 1.94 in FO). No differences were observed in plasma metabolites except for cholesterol that was lower in FO group (56.25 ± 0.71 vs. 53.09 ± 0.61). Milk fat percentage was reduced (8.82 ± 0.49 vs. 7.03 ± 0.45) while the percentage of milk total n-3 LCFA increased in FO group. In accordance, the relative transcript abundance of miR-101 (0.215 ± 0.08) and miR-103 (0.37 ± 0.15) decreased by FO supplementation. Results showed that FO supplementation during peripartal period decreased milk fat, feed intake, plasma cholesterol, milk n-6:n-3 ratio and the expression of miR-101. Although the trend indicated that FO could alter lipid metabolism during transition period, further studies are needed to fully address its effect on energy balance and homeorhetic processes.

Keywords

Long chain fatty acids Metabolite MicroRNA Peripartum period.
Sheibani, S., Mohammadi-Sangcheshmeh, A., Alamouti, A. A., Khadem, A. A., & Norouzian, M. A. (2017). Metabolic and molecular responses to calcium soap of fish oil fed to ewes during peripartal period. Cellular and Molecular Biology, 63(10), 4–10. https://doi.org/10.14715/cmb/2017.63.10.2
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