Issue

Vol. 64 No. 3: Issue 3

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat

https://doi.org/10.14715/cmb/2018.64.3.1
Mehmet Celer
Deparment of Physiology, Medical Faculty, Selcuk University, Konya, Turkey
Rasim Mogulkoc
Deparment of Physiology, Medical Faculty, Selcuk University, Konya, Turkey
Abdulkerim Kasim Baltaci
Deparment of Physiology, Medical Faculty, Selcuk University, Konya, Turkey
Dervis Dasdelen
Deparment of Physiology, Medical Faculty, Selcuk University, Konya, Turkey

Corresponding Author(s) : Rasim Mogulkoc

rasimmogulkoc@yahoo.com

Cellular and Molecular Biology, Vol. 64 No. 3: Issue 3

Abstract

Ischemia-reperfusion leads to damage in cell or tissue due to insufficient blood flow. The aim of present study was to determine the effect of zinc, melatonin and zinc + melatonin supplementations during 3 weeks on muscle tissue and plasma MDA and GSH levels. This study was performed on 38 male Wistar-Albino rats. Experiments groups were designed as sham-control, ischemia-reperfusion (I/R), zinc + I/R, melatonin + I/R and zinc + melatonin + I/R Ischemia-reperfusion was induced by left femoral artery occlusion (1 hour) and reopening (1 hour).  At the end of experiments tissue and blood samples were analysed for MDA and GSH. MDA levels were increased, GSH levels decreased in I/R groups. However, zinc and melatonin supplementation inhibited  MDA and increased GSH levels in I/R groups. The results of present study show that increased lipid peroxidation in muscle tissue by ischemia-reperfusion may be prevented by zinc and melatonin or zinc plus melatonin supplementation.

Keywords

Ischemia-reperfusion Muscle Zinc Melatonin Free radical.
Celer, M., Mogulkoc, R., Baltaci, A. K., & Dasdelen, D. (2018). The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat. Cellular and Molecular Biology, 64(3), 1–4. https://doi.org/10.14715/cmb/2018.64.3.1
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. References
  2. -Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol. 2015; 6: 524-51.
  3. -Shi S, Xue F. Current Antioxidant Treatments in Organ Transplantation. Oxid Med Cell Longev. 2016:8678510.
  4. -Dillon JP, Laing AJ, Chandler JR, Wang JH, McGuinness A, Redmond HP. Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury. Acta Orthop. 2006; 77: 27-32.
  5. -Ayada C, Toru íœ, Genç O, Akcılar R, Åžahin S. Balanced oxidative status by nesfatin-1 in intestinal ischemia-reperfusion. Int J Clin Exp Med. 2015; 8: 3318-24.
  6. -Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, Filip M. Oxidative Stress in Neurodegenerative Diseases. Mol Neurobiol. 2016; 53: 4094-125.
  7. -Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 2012; 48: 158-67.
  8. -Ghneim HK, Al-Sheikh YA, Alshebly MM, Aboul-Soud MA. Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage. Mol Med Rep. 2016; 13: 2606-12.
  9. -MacDiarmid CW, Taggart J, Jeong J, Kerdsomboon K, Eide DJ. Activation of the yeast UBI4 polyubiquitin gene by Zap1 via an intragenic promoter is critical for zinc-deficient growth. J Biol Chen. 2016; 291:18880-96.
  10. -Rice JM, Zweifach A, Lynes MA. Metallothionein regulates intracellular zinc signaling during CD4+ T cell activation. BMC Immunol. 2016; 17:13.
  11. -Nishiwaki-Ohkawa T, Yoshimura T. Molecular basis for regulating seasonal reproduction in vertebrates. J Endocrinol. 2016; 229: 117-27.
  12. -Yang P, Liu H, Lin J, Yang H. The Association of rs4753426 Polymorphism in the Melatonin Receptor 1B (MTNR1B) Gene and Susceptibility to Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-analysis. Pain Physician. 2015: 18: 419-31.
  13. -Uchiyama M, Miharama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978; 86: 271-8.
  14. -Ellman GL. Tissue sulfhydryl groups. Arc Biochem Biophysics 1959; 82:70-7.
  15. -Ghaly A, Marsh DR. Ischaemia-reperfusion modulates inflammation and fibrosis of skeletal muscle after contusion injury. Int J Exp Pathol. 2010; 91: 244-255.
  16. -Tong Z, Yu F, Liu Z, Liang H. Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals skeletal muscle. Molecules. 2012; 17: 8494-8505.
  17. -Walters TJ, Mase VJ Jr, Roe JL, Dubick MA, Christy RJ. Poloxamer-188 reduces muscular edema after tourniquet-induced ischemia-reperfusion injury in rat. J Trauma. 2011;70:1192-7.
  18. -Gurji HA, White DW, Hoxha B, Sun J, Harbor JP, Schulz DR, Williams AG Jr, Olivencia-Yurvati AH, Mallet RT. Pyruvate-enriched resuscitation: metabolic support of post-ischemic hindlimb muscle in hypovolemic goats. Exp Biol Med (Maywood). 2014; 239: 240-9.
  19. -Kirisci M, Oktar GL, Ozogul C, Oyar EO, Akyol SN, Demirtas CY, Arslan M. Effects of adrenomedullin and vascular endothelial growth factor on ischemia/reperfusion injury in skeletal muscle in rats. J Surg Res. 2013; 185: 56-63.
  20. -Mahbooba M, Siddiquib MKJ. Long-term effects of a novel phosphorothionate (RPRII) on detoxifying enzymes in brain, lung and kidney rats. Ecotoxicology and Environmental Safety. 2002; 53: 355-60.
  21. -Baltacı AK, Sunar F, Mogulkoc R, Oztekın E. Effect of zinc deficiency and supplementation on lipid peroxidation of renal tissue in ovariectomized rats. Biol Trace Elem Res. 2004; 101: 231-9.
  22. -Ahmadiasl N, Banaei S, Alihemati A, Baradaran B, Azimian E. Effect of a combined treatment with erythropoietin and melatonin on renal ischemia reperfusion injury in male rats. Clin Exp Nephrol. 2014; 18: 855-864.
  23. -Ahmadiasl N, Banaei S, Alihemmati A. Combination antioxidant effect of erythropoietin and melatonin on renal ischemia-reperfusion injury in rats. Iran J Basic Med Sci. 2013;16: 1209-16.
  24. -Lin CL, Tseng HC, Chen RF, Chen WP, Su MJ, Fang KM, Wu ML. Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury. Cell Death Differ. 2011; 18: 1651-63.
  25. -Kansal SK, Jyoti U, Sharma S, Kaura A, Deshmukh R, Goyal S. Effect of zinc supplements in the attenuated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart. Naunyn Schmiedebergs Arch Pharmacol. 2015; 388: 635-41.
  26. -Zeng X, Tan X. Epigallocatechin-3-gallate and zinc provide anti-apoptotic protection against hypoxia/reoxygenation injury in H9c2 rat cardiac myoblast cells. Mol Med Rep. 2015; 12: 1850-6.
  27. -Erdem M, Bostan B, Güneş T, í–zkan F, Sen C, í–zyurt H, Köseoğlu RD, Erdoğan H. Protective effects of melatonin on ischemia-reperfusion injury of skeletal muscle. Eklem Hastalik Cerrahisi. 2010; 21: 166-71.
  28. -Wang WZ, Fang XH, Stephenson LL, Zhang X, Khiabani KT, Zamboni WA. Melatonin attenuates I/R-induced mitochondrial dysfunction in skeletal muscle. J Surg Res. 2011; 171: 108-13.
  29. -Sanchez-Hidalgo M, De la Lastra CA, Carrascosa-Salmoral MP, Naranjo MC, Gomez-Corvere A, Caballero B, Guerrero JM. Age-related changes in melatonin synthesis in rat extrapineal tissues. Exp Gerontol. 2009; 44: 328-34.
  30. -Farí­as JG, Zepeda AB, Calaf GM. Melatonin Protects the Heart, Lungs and Kidneys from Oxidative Stress under Intermittent Hypobaric Hypoxia in Rats. Biol Res. 2012; 45: 81-5.
  31. -Atahan E, Ergün Y, Kurutaş EB, Alici T. Protective effect of zinc aspartate on long-term ischemia-reperfusion injury in rat skeletal muscle. Biol Trace Elem Res. 2010; 137: 206-15.
  32. -Atahan E, Ergun Y, Belge Kurutas E, Cetinus E, Guney Ergun U. Ischemia-reperfusion injury in rat skeletal muscle is attenuated by zinc aspartate. J Surg Res. 2007; 137: 109-116.
  33. -Bulbuloglu E, Yildiz H, Senoglu N, Coskuner I, Yuzbasioglu MF, Kilinc M, Dogan Z, Deniz C, Oksuz H, Kantarçeken B, Atli Y. Protective effects of zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the small intestine. J Laparoendosc Adv Surg Tech A. 2011; 21: 947-51.
  34. -Yilmaz M, Mogulkoc R, Baltaci AK. Effect of three-week zinc and melatonin supplementation on the oxidant-antioxıdant system in experimental renal ischemia-reperfusion in rats. Acta Clin Croat. 2015; 54: 395-401.
  35. -Liu LF, Qin Q, Qian ZH, Shi M, Deng QC, Zhu WP, Zhang H, Tao XM, Liu Y. Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats. Eur Rev Med Pharmacol Sci. 2014; 18: 3681-6.
  36. -Deng J, Liu W, Wang Y, Dong M, Zheng M, Liu J. Polydatin modulates Ca(2+) handling, excitation-contraction coupling and β-adrenergic signaling in rat ventricular myocytes. J Mol Cell Cardiol. 2012; 53: 646-56.
  37. -Aydemir S, Dogan D, Kocak A, Dilsiz N. The effect of melatonin on spinal cord after ischemia in rats. Spinal Cord. 2016; 54: 360-3.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 1023 Download : 417

Most read articles by the same author(s)