Serum levels of IL-31, IL-33 and ST2 in allergic rhinitis of children in China

Yi Qiao; Jie Chen

doi:10.14715/cmb/2018.64.12.11

Issue

Vol. 64 No. 12: Issue 12

Issue Published : October 2, 2018

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Serum levels of IL-31, IL-33 and ST2 in allergic rhinitis of children in China

https://doi.org/10.14715/cmb/2018.64.12.11

Yi Qiao

Department of Otorhinolaryngology, Shanghai Children's Medical Center Affiliated to the Medical School of Shanghai Jiaotong University, China

Jie Chen

Department of Otorhinolaryngology, Shanghai Children's Medical Center Affiliated to the Medical School of Shanghai Jiaotong University, China

Corresponding Author(s) : Jie Chen

hwen9308588@sina.com

Cellular and Molecular Biology, Vol. 64 No. 12: Issue 12
Article Published : September 30, 2018

Abstract

This study aimed to compare the serum levels of IL-31, IL-33 and ST2 in children patients with allergic rhinitis (AR) and allergic asthma and tried to reveal more insights in development of AR. Thirty-six children patients with intermittent AR were selected in the present study during January 2013 to December 2016. Two control groups were set, the allergic asthma group and the healthy individuals. Atopic status of all participants in this study was tested and confirmed by skin prick testing (SPT). Levels of IL-31, IL-33 and ST2 were determined using ELISA. Statistical analysis was performed by SPSS 18.0. There is no significant difference in age, gender ratio and BMI for all patients. However, positive ratio of SPT and total IgE in patients' groups were significantly higher than the control group. Levels of IL-33 and IL-31 in both AR and allergic asthma group were significantly higher than those of the control group, P<0.05. However, level of ST2 in the three groups didn't show significant difference. Correlation analysis showed that there was a positive correlation between levels of IL-33 and IL-31, P<0.05. However, levels of ST2 and IL-33, ST2 and IL-31 were not significantly correlated. The serum levels of IL-33 and IL-31 were significantly up-regulated in both AR and allergic asthma patients compared with normal individuals. These results could provide more clinical evidences for understanding roles of IL-33, IL-31 and ST2 in children patients with allergic rhinitis.

Keywords

IL-33 IL-31 Allergic rhinitis.

Qiao, Y., & Chen, J. (2018). Serum levels of IL-31, IL-33 and ST2 in allergic rhinitis of children in China. Cellular and Molecular Biology, 64(12), 52–55. https://doi.org/10.14715/cmb/2018.64.12.11

Download Citation

References

L. The, Allergic rhinitis: common, costly, and neglected, The Lancet 371 (2008) 2057.
R. Nasiri, M. Movahedi, A.A. Amirzargar, A. Hirbod-Mobarakeh, E. Farhadi, B. Ansaripour, B. Moradi, N. Rezaei, Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis, Int J Pediatr Otorhinolaryngol 78 (2014) 1426-1429.
M.-T.A. Torres-Borrego J, Montes-Mendoza C, Prevalence and associated factors of allergic rhinitis and atopic dermatitis in children, Allergol Immunopathol (Madr) 36 (2008) 90-100.
C.W. Li, H.G. Lu, D.H. Chen, Z.B. Lin, D.Y. Wang, T.Y. Li, In vivo and in vitro studies of Th17 response to specific immunotherapy in house dust mite-induced allergic rhinitis patients, PLoS One 9 (2014) e91950.
Y.Y. Xu, X. Liu, L.B. Dai, S.H. Zhou, Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis, J Chin Med Assoc 75 (2012) 524-529.
J. Louten, A.L. Rankin, Y. Li, E.E. Murphy, M. Beaumont, C. Moon, P. Bourne, T.K. McClanahan, S. Pflanz, R. de Waal Malefyt, Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation, Int Immunol 23 (2011) 307-315.
C.M. Williams, S. Rahman, C. Hubeau, H.L. Ma, Cytokine pathways in allergic disease, Toxicol Pathol 40 (2012) 205-215.
R. Saluja, M.E. Ketelaar, T. Hawro, M.K. Church, M. Maurer, M.C. Nawijn, The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders, Mol Immunol 63 (2015) 80-85.
M.A. Rank, T. Kobayashi, H. Kozaki, K.R. Bartemes, D.L. Squillace, H. Kita, IL-33-activated dendritic cells induce an atypical TH2-type response, J Allergy Clin Immunol 123 (2009) 1047-1054.
J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy, T.K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, D.M. Gorman, J.F. Bazan, R.A. Kastelein, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity 23 (2005) 479-490.
Y.S. Hong, S.J. Moon, Y.B. Joo, C.H. Jeon, M.L. Cho, J.H. Ju, H.J. Oh, Y.J. Heo, S.H. Park, H.Y. Kim, J.K. Min, Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis, J Korean Med Sci 26 (2011) 1132-1139.
H. Hayakawa, M. Hayakawa, A. Kume, S. Tominaga, Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation, J Biol Chem 282 (2007) 26369-26380.
Z. Allakhverdi, D.E. Smith, M.R. Comeau, G. Delespesse, Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells, The Journal of Immunology 179 (2007) 2051-2054.
Y. Baba, K. Maeda, T. Yashiro, E. Inage, K. Kasakura, R. Suzuki, F. Niyonsaba, M. Hara, A. Tanabe, H. Ogawa, K. Okumura, Y. Ohtsuka, T. Shimizu, C. Nishiyama, GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression, J Biol Chem 287 (2012) 32689-32696.
M.E. Ketelaar, K.D. van de Kant, F.N. Dijk, E.M. Klaassen, N.S. Grotenboer, M.C. Nawijn, E. Dompeling, G.H. Koppelman, Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO, Allergy (2017).
J. Gluck, B. Rymarczyk, B. Rogala, Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity, Inflamm Res 61 (2012) 547-550.
S. Kim, H.J. Kim, H.S. Yang, E. Kim, I.S. Huh, J.M. Yang, IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis, Ann Dermatol 23 (2011) 468-473.
A. Bonanno, S. Gangemi, S. La Grutta, V. Malizia, L. Riccobono, P. Colombo, F. Cibella, M. Profita, 25-Hydroxyvitamin D, IL-31, and IL-33 in children with allergic disease of the airways, Mediators Inflamm 2014 (2014) 520241.
B.J. Brozek JL, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, van Wijk RG, Ohta K, Zuberbier T, Schünemann HJ., Global Allergy and Asthma European Network; Grading of Recommendations Assessment, Development and Evaluation Working Group, J Allergy Clin Immunol 126 (2010) 466-476.
K. C, Global Initiative for Asthma (GINA) guidelines: 15 years of application, Expert Rev Clin Immunol 5 (2014) 239-249.
S. Dreborg, A. Frew, Position Paper: Allergen standardization and skin tests, Allergy 48 (1993) 49-54.
M. Feld, V.M. Shpacovitch, M. Fastrich, F. Cevikbas, M. Steinhoff, Interferon-gamma induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells, Exp Dermatol 19 (2010) 921-923.
B.S. Kim, M.C. Siracusa, S.A. Saenz, M. Noti, L.A. Monticelli, G.F. Sonnenberg, M.R. Hepworth, A.S. Van Voorhees, M.R. Comeau, D. Artis, TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation, Sci Transl Med 5 (2013) 170ra116.
L. Vocca, C. Di Sano, C.G. Uasuf, A. Sala, L. Riccobono, S. Gangemi, G.D. Albano, A. Bonanno, R. Gagliardo, M. Profita, IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases, Immunobiology 220 (2015) 954-963.
Y.S. Nakanishi W, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S, IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis, PLoS One 8 (2013) e78099.

References

L. The, Allergic rhinitis: common, costly, and neglected, The Lancet 371 (2008) 2057.

R. Nasiri, M. Movahedi, A.A. Amirzargar, A. Hirbod-Mobarakeh, E. Farhadi, B. Ansaripour, B. Moradi, N. Rezaei, Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis, Int J Pediatr Otorhinolaryngol 78 (2014) 1426-1429.

M.-T.A. Torres-Borrego J, Montes-Mendoza C, Prevalence and associated factors of allergic rhinitis and atopic dermatitis in children, Allergol Immunopathol (Madr) 36 (2008) 90-100.

C.W. Li, H.G. Lu, D.H. Chen, Z.B. Lin, D.Y. Wang, T.Y. Li, In vivo and in vitro studies of Th17 response to specific immunotherapy in house dust mite-induced allergic rhinitis patients, PLoS One 9 (2014) e91950.

Y.Y. Xu, X. Liu, L.B. Dai, S.H. Zhou, Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis, J Chin Med Assoc 75 (2012) 524-529.

J. Louten, A.L. Rankin, Y. Li, E.E. Murphy, M. Beaumont, C. Moon, P. Bourne, T.K. McClanahan, S. Pflanz, R. de Waal Malefyt, Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation, Int Immunol 23 (2011) 307-315.

C.M. Williams, S. Rahman, C. Hubeau, H.L. Ma, Cytokine pathways in allergic disease, Toxicol Pathol 40 (2012) 205-215.

R. Saluja, M.E. Ketelaar, T. Hawro, M.K. Church, M. Maurer, M.C. Nawijn, The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders, Mol Immunol 63 (2015) 80-85.

M.A. Rank, T. Kobayashi, H. Kozaki, K.R. Bartemes, D.L. Squillace, H. Kita, IL-33-activated dendritic cells induce an atypical TH2-type response, J Allergy Clin Immunol 123 (2009) 1047-1054.

J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy, T.K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, D.M. Gorman, J.F. Bazan, R.A. Kastelein, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity 23 (2005) 479-490.

Y.S. Hong, S.J. Moon, Y.B. Joo, C.H. Jeon, M.L. Cho, J.H. Ju, H.J. Oh, Y.J. Heo, S.H. Park, H.Y. Kim, J.K. Min, Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis, J Korean Med Sci 26 (2011) 1132-1139.

H. Hayakawa, M. Hayakawa, A. Kume, S. Tominaga, Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation, J Biol Chem 282 (2007) 26369-26380.

Z. Allakhverdi, D.E. Smith, M.R. Comeau, G. Delespesse, Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells, The Journal of Immunology 179 (2007) 2051-2054.

Y. Baba, K. Maeda, T. Yashiro, E. Inage, K. Kasakura, R. Suzuki, F. Niyonsaba, M. Hara, A. Tanabe, H. Ogawa, K. Okumura, Y. Ohtsuka, T. Shimizu, C. Nishiyama, GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression, J Biol Chem 287 (2012) 32689-32696.

M.E. Ketelaar, K.D. van de Kant, F.N. Dijk, E.M. Klaassen, N.S. Grotenboer, M.C. Nawijn, E. Dompeling, G.H. Koppelman, Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO, Allergy (2017).

J. Gluck, B. Rymarczyk, B. Rogala, Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity, Inflamm Res 61 (2012) 547-550.

S. Kim, H.J. Kim, H.S. Yang, E. Kim, I.S. Huh, J.M. Yang, IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis, Ann Dermatol 23 (2011) 468-473.

A. Bonanno, S. Gangemi, S. La Grutta, V. Malizia, L. Riccobono, P. Colombo, F. Cibella, M. Profita, 25-Hydroxyvitamin D, IL-31, and IL-33 in children with allergic disease of the airways, Mediators Inflamm 2014 (2014) 520241.

B.J. Brozek JL, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, van Wijk RG, Ohta K, Zuberbier T, Schünemann HJ., Global Allergy and Asthma European Network; Grading of Recommendations Assessment, Development and Evaluation Working Group, J Allergy Clin Immunol 126 (2010) 466-476.

K. C, Global Initiative for Asthma (GINA) guidelines: 15 years of application, Expert Rev Clin Immunol 5 (2014) 239-249.

S. Dreborg, A. Frew, Position Paper: Allergen standardization and skin tests, Allergy 48 (1993) 49-54.

M. Feld, V.M. Shpacovitch, M. Fastrich, F. Cevikbas, M. Steinhoff, Interferon-gamma induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells, Exp Dermatol 19 (2010) 921-923.

B.S. Kim, M.C. Siracusa, S.A. Saenz, M. Noti, L.A. Monticelli, G.F. Sonnenberg, M.R. Hepworth, A.S. Van Voorhees, M.R. Comeau, D. Artis, TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation, Sci Transl Med 5 (2013) 170ra116.

L. Vocca, C. Di Sano, C.G. Uasuf, A. Sala, L. Riccobono, S. Gangemi, G.D. Albano, A. Bonanno, R. Gagliardo, M. Profita, IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases, Immunobiology 220 (2015) 954-963.

Y.S. Nakanishi W, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S, IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis, PLoS One 8 (2013) e78099.

Author biographies is not available.