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Status of lymphatic filariasis with progression of age and gender & eradication strategies: A survey among residents of Hardoi district of Uttar Pradesh, an endemic region of North India
Corresponding Author(s) : Mohd Saeed
Cellular and Molecular Biology,
Vol. 64 No. 4: Issue 4
Abstract
Lymphatic filariasis (LF) is a chronic and debilitating disease that affects people in tropical and sub-tropical areas of Asia, Africa, and Western Pacific. It is one of the leading community health problems in some of the endemic districts in India including Hardoi district of Uttar Pradesh. The disease is caused by the parasites Wuchereria bancrofti (W. bancrofti), Brugia malayi (B. malayi) and Brugia timori (B. timori), transmitted by the vector Culex, Anopheles and other mosquitoes. This cross-sectional survey study was carried out in rural areas, where its inhabitants vary in socio-economic status, from low to middle-income class. 12 villages of Hardoi district, Uttar Pradesh, India were included. The aim was to see the impact of age and gender on various clinical forms of LF and in estimating its economic and social implications. 260 LF affected people in different parts of Hardoi district were surveyed. The results revealed that the Mass Drug Administration (MDA) coverage reached more than 90%. The overall Microfilaria rate had been reduced, however the prevalence of elephantiasis increased with the progression of age and was found to be highest among people of >70 years of age, regardless of their gender.
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- Saeed, M., Al-Shammari, E. M., Khan, S., Alam, M. J., & Adnan, M. (2016). Monitoring and evaluation of lymphatic filariasis interventions: current trends for diagnosis. Reviews in Medical Microbiology, 27(2), 75-83.
- Koroma, J. B., Bangura, M. M., Hodges, M. H., Bah, M. S., Zhang, Y., and Bockarie, M. J. (2012). Lymphatic filariasis mapping by Immunochromatographic Test cards and baseline microfilaria survey prior to mass drug administration in Sierra Leone. Parasit Vectors, 5(10).
- Chu BK, Hooper PJ, Bradley MH, McFarland DA, and Ottesen EA (2010).The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007). PLoS neglected tropical diseases, 4(6):708.
- WHO Lymphatic filariasis Fact sheet Updated October 2017 (http://www.who.int/mediacentre/factsheets/fs102/en)
- Lustigman, S., Prichard, R. K., Gazzinelli, A., Grant, W. N., Boatin, B. A., McCarthy, J. S., and Basáñez, M. G. (2012). A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4), -1582.
- Ruberanziza E, Mupfasoni D, Karibushi B, Rujeni N, Kabanda G, Kabera M, Kaberuka T, Nizeyimana V, Kramer MH, Mukabayire O, et al., (2009) Mapping of lymphatic filariasis in Rwanda. Journal of Lymphoedema, 4(1):20-23.
- Bockarie MJ, and Molyneux DH (2009). The end of lymphatic filariasis?British Medical Journal (BMJ) 338: 1686.
- Ottesen EA, Duke BO, Karam M, Behbehani K (1997) Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ, 75(6):491-503.
- Addiss D (2010). The 6th Meeting of the Global Alliance to Eliminate Lymphatic Filariasis: A half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases. Parasit Vectors, 3(1):100.
- Gyapong JO, Kumaraswami V, Biswas G, and Ottesen EA (2005).Treatment strategies underpinning the global programme to eliminate lymphatic filariasis.Expert Opin Pharmacother, 6(2):179-200.
- Iboh, C. I., Okon, O. E., Opara, K. N., Asor, J. E. and Etim, S. E. (2012). Lymphatic filariasis among the Yakurr people of Cross River State, Nigeria.Parasites & vectors, 5(1), 1-5.
- Saeed, M., Baig, M. H., Bajpai, P., Srivastava, A. K., Ahmad, K., & Mustafa, H. (2013). Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids. Bioinformation, 9(5), 233.
- WHO: Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions Geneva: World Health Organization; 2006.
- Linehan M, Hanson C, Weaver A, Baker M, Kabore A, Zoerhoff KL, Sankara D, Torres S and Ottesen EA. (2011). Integrated implementation of programs targeting neglected tropical diseases through preventive chemotherapy: proving the feasibility at national scale. The American journal of tropical medicine and hygiene, 84(1), 5.
- Mullner, A., Helfer, A., Kotlyar, D., Oswald, J., and Efferth, T. (2011). Chemistry and pharmacology of neglected helminthic diseases. Current medicinal chemistry, 18(5), 767-789.
- Saeed, M., Baig, M. H., Bajpai, P., Srivastava, A. K., Ahmad, K., & Mustafa, H. (2013). Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids. Bioinformation, 9(5), 233.
- Frimpong, S. (2012). Effects of lymphatic filariasis on the socio-economic life of the people of Narkwa in the Mfantseman municipality of the Central region of Ghana (Abstract)
- Saeed, M., Siddiqui, S., Bajpai, P., Srivastava, A. K., & Mustafa, H. (2014). Amplification of Brugia malayi DNA using Hha1 Primer as a Tool. In The Open Conference Proceedings Journal (Vol. 5, pp. 38-40).
- Auty HK, Picozzi K, Malele I, Torr SJ, Cleaveland S, and Welburn S (2012). Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania. PLoS neglected tropical diseases, 6(1), e 1501
- Basáñez MG, McCarthy JS, French MD, Yang GJ, Walker M, Gambhir M, and Churcher TS (2012). A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS neglected tropical diseases, 6(4) : 1548.
- Chandrashekar R, Curtis KC, Ramzy RM, Liftis F, Li B and Weil GJ (1994).Improvement and Application of a Polymerase Chain Reaction System for Detection of Wuchereria bancrofti in culex quinquefasciatus and Human Blood Samples.Molecular cloning of Brugia malayi antigen for diagnosis of lymphatic filariasis. Mol. Biochem. Parasitol.64: 261–71.
- Chandrashekar, R (1997). Recent advances in diagnosis of filarial infections. Indian journal of experimental biology, 35(1), 18.
- Sorosjinda-Nunthawarasilp, P. (2013). Current Bancroftian Filariasis Elimination on Thailand-Myanmar Border: Public Health Challenges toward Postgenomic MDA Evaluation. ISRN Tropical Medicine,
- Dash AP, Mohapata N, Hazra RK, and Acharya AS (1998). Transmission dynamics of filariasis in Khurda district of Orissa, India. Southeast Asian J Trop Med Public Health 29: 137-40.
- Pani SP, Balakrishnan N, Srividya A, Bundy DAP and Grenfell BT. (1991) Clinical epidemiology of bancroftian filariasis: effect of age and gender. Trans R Soc Trop Med Hyg85: 260-4.
- Ramaiah KD, Ramu K, Vijaykumar KN, and Guyatt H (1996).Epidemiology of acute filarial episodes caused by Wuchereria bancrofti infection in two rural villages in Tamil Nadu, South India.Trans R Soc Trop Med Hyg 90: 639.
- Sharma RVSN, Vallishayee RS, Mayurnath S, Narayanan PR, Radhamani MP and Tripathy SP. (1987) Prevalence survey of filariasis in two villages in Chingleput district of Tamil Nadu. Indian J Med Res 85: 522-30.
- Sharma S, Sharma M and Rathur S. (1999) Bancroftian filariasis in the Varanasi region of north India: an epidemiological study. Ann Trop Med Parasitol 93: 379-87.
- Brabin L. (1990). Sex differentials in susceptibility to lymphatic filariasis and implications for maternal child immunity.Epidemiol Infect 105: 335-353.
- Melrose, W. D., Durrheim, D. D., and Burgess, G. W. (2004). Update on immunological tests for lymphatic filariasis. Trends in parasitology, 20(6), 255-257.
References
Saeed, M., Al-Shammari, E. M., Khan, S., Alam, M. J., & Adnan, M. (2016). Monitoring and evaluation of lymphatic filariasis interventions: current trends for diagnosis. Reviews in Medical Microbiology, 27(2), 75-83.
Koroma, J. B., Bangura, M. M., Hodges, M. H., Bah, M. S., Zhang, Y., and Bockarie, M. J. (2012). Lymphatic filariasis mapping by Immunochromatographic Test cards and baseline microfilaria survey prior to mass drug administration in Sierra Leone. Parasit Vectors, 5(10).
Chu BK, Hooper PJ, Bradley MH, McFarland DA, and Ottesen EA (2010).The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007). PLoS neglected tropical diseases, 4(6):708.
WHO Lymphatic filariasis Fact sheet Updated October 2017 (http://www.who.int/mediacentre/factsheets/fs102/en)
Lustigman, S., Prichard, R. K., Gazzinelli, A., Grant, W. N., Boatin, B. A., McCarthy, J. S., and Basáñez, M. G. (2012). A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4), -1582.
Ruberanziza E, Mupfasoni D, Karibushi B, Rujeni N, Kabanda G, Kabera M, Kaberuka T, Nizeyimana V, Kramer MH, Mukabayire O, et al., (2009) Mapping of lymphatic filariasis in Rwanda. Journal of Lymphoedema, 4(1):20-23.
Bockarie MJ, and Molyneux DH (2009). The end of lymphatic filariasis?British Medical Journal (BMJ) 338: 1686.
Ottesen EA, Duke BO, Karam M, Behbehani K (1997) Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ, 75(6):491-503.
Addiss D (2010). The 6th Meeting of the Global Alliance to Eliminate Lymphatic Filariasis: A half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases. Parasit Vectors, 3(1):100.
Gyapong JO, Kumaraswami V, Biswas G, and Ottesen EA (2005).Treatment strategies underpinning the global programme to eliminate lymphatic filariasis.Expert Opin Pharmacother, 6(2):179-200.
Iboh, C. I., Okon, O. E., Opara, K. N., Asor, J. E. and Etim, S. E. (2012). Lymphatic filariasis among the Yakurr people of Cross River State, Nigeria.Parasites & vectors, 5(1), 1-5.
Saeed, M., Baig, M. H., Bajpai, P., Srivastava, A. K., Ahmad, K., & Mustafa, H. (2013). Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids. Bioinformation, 9(5), 233.
WHO: Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions Geneva: World Health Organization; 2006.
Linehan M, Hanson C, Weaver A, Baker M, Kabore A, Zoerhoff KL, Sankara D, Torres S and Ottesen EA. (2011). Integrated implementation of programs targeting neglected tropical diseases through preventive chemotherapy: proving the feasibility at national scale. The American journal of tropical medicine and hygiene, 84(1), 5.
Mullner, A., Helfer, A., Kotlyar, D., Oswald, J., and Efferth, T. (2011). Chemistry and pharmacology of neglected helminthic diseases. Current medicinal chemistry, 18(5), 767-789.
Saeed, M., Baig, M. H., Bajpai, P., Srivastava, A. K., Ahmad, K., & Mustafa, H. (2013). Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids. Bioinformation, 9(5), 233.
Frimpong, S. (2012). Effects of lymphatic filariasis on the socio-economic life of the people of Narkwa in the Mfantseman municipality of the Central region of Ghana (Abstract)
Saeed, M., Siddiqui, S., Bajpai, P., Srivastava, A. K., & Mustafa, H. (2014). Amplification of Brugia malayi DNA using Hha1 Primer as a Tool. In The Open Conference Proceedings Journal (Vol. 5, pp. 38-40).
Auty HK, Picozzi K, Malele I, Torr SJ, Cleaveland S, and Welburn S (2012). Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania. PLoS neglected tropical diseases, 6(1), e 1501
Basáñez MG, McCarthy JS, French MD, Yang GJ, Walker M, Gambhir M, and Churcher TS (2012). A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS neglected tropical diseases, 6(4) : 1548.
Chandrashekar R, Curtis KC, Ramzy RM, Liftis F, Li B and Weil GJ (1994).Improvement and Application of a Polymerase Chain Reaction System for Detection of Wuchereria bancrofti in culex quinquefasciatus and Human Blood Samples.Molecular cloning of Brugia malayi antigen for diagnosis of lymphatic filariasis. Mol. Biochem. Parasitol.64: 261–71.
Chandrashekar, R (1997). Recent advances in diagnosis of filarial infections. Indian journal of experimental biology, 35(1), 18.
Sorosjinda-Nunthawarasilp, P. (2013). Current Bancroftian Filariasis Elimination on Thailand-Myanmar Border: Public Health Challenges toward Postgenomic MDA Evaluation. ISRN Tropical Medicine,
Dash AP, Mohapata N, Hazra RK, and Acharya AS (1998). Transmission dynamics of filariasis in Khurda district of Orissa, India. Southeast Asian J Trop Med Public Health 29: 137-40.
Pani SP, Balakrishnan N, Srividya A, Bundy DAP and Grenfell BT. (1991) Clinical epidemiology of bancroftian filariasis: effect of age and gender. Trans R Soc Trop Med Hyg85: 260-4.
Ramaiah KD, Ramu K, Vijaykumar KN, and Guyatt H (1996).Epidemiology of acute filarial episodes caused by Wuchereria bancrofti infection in two rural villages in Tamil Nadu, South India.Trans R Soc Trop Med Hyg 90: 639.
Sharma RVSN, Vallishayee RS, Mayurnath S, Narayanan PR, Radhamani MP and Tripathy SP. (1987) Prevalence survey of filariasis in two villages in Chingleput district of Tamil Nadu. Indian J Med Res 85: 522-30.
Sharma S, Sharma M and Rathur S. (1999) Bancroftian filariasis in the Varanasi region of north India: an epidemiological study. Ann Trop Med Parasitol 93: 379-87.
Brabin L. (1990). Sex differentials in susceptibility to lymphatic filariasis and implications for maternal child immunity.Epidemiol Infect 105: 335-353.
Melrose, W. D., Durrheim, D. D., and Burgess, G. W. (2004). Update on immunological tests for lymphatic filariasis. Trends in parasitology, 20(6), 255-257.