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Vol. 64 No. 4: Issue 4

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TW37 enhances the pro-apoptosis and anti-migration ability of gefitinib in Non-Small Cell Lung Cancer

https://doi.org/10.14715/cmb/2018.64.4.2
Xiaofan Chen
Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China
Guangxian Mao
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Hua Chen
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Suyue Liu
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Sichao Wang
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Xiaoqiang Li
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Yiwang Ye
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Hao Wu
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Jixian Liu
Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

Corresponding Author(s) : Jixian Liu

liujixiancmb@163.com

Cellular and Molecular Biology, Vol. 64 No. 4: Issue 4

Abstract

B cell leukemia-2 (Bcl-2) plays important roles in the development of tumor and drug resistance. The growth of tumor cells can be inhibited by downregulating the abnormal expression of Bcl-2 protein. TW37, an effective inhibitor of Bcl-2 protein, has now been widely studied in many tumors. In our study, it was found that TW37 exerted a significant effect on the proliferation, apoptosis and migration of Non-Small Cell Lung Cancer cells. Bcl-2 is also a key downstream factor of many signaling pathways such as Epidermal Growth Factor Receptor (EGFR). TW37 enhanced the inhibition of tumorigenesis by gefitinib, an EGFR-Tyrosine Kinase Inhibitor drug. Moreover, TW37 can promote apoptosis ability by inhibiting the phosphorylation level of EGFR protein in H1975 cells. Overall, TW37 enhances the pro-apoptosis and anti-migration ability of gefitinib in Non-Small Cell Lung Cancer.

Keywords

TW37 Gefitinib Apoptosis Migration Non-Small Cell Lung Cancer.
Chen, X., Mao, G., Chen, H., Liu, S., Wang, S., Li, X., Ye, Y., Wu, H., & Liu, J. (2018). TW37 enhances the pro-apoptosis and anti-migration ability of gefitinib in Non-Small Cell Lung Cancer. Cellular and Molecular Biology, 64(4), 6–10. https://doi.org/10.14715/cmb/2018.64.4.2
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