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Vol. 64 No. 13: Issue 13

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Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti

https://doi.org/10.14715/cmb/2018.64.13.13
Mohd Saeed
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, KSA
Mohd Imran
Department of Biophysics, All India Institute of Medical Sciences, Ansari nagar, New Delhi, 110029, India
Mohd Hassan Baig
Department of Medical Biotechnology, Yeungnam University, The Republic of Korea
Mohd Adnan Kausar
Department of Biochemistry, college of Medicine, University of Hail, KSA
SMA Shahid
Department of Biochemistry, college of Medicine, University of Hail, KSA
Irfan Ahmad
Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Khalid University. Abha, KSA

Corresponding Author(s) : Mohd Hassan Baig

mohdhassanbaig@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 13: Issue 13

Abstract

Glutathione-S-transferase also referred as GST is one of the major detoxification enzymes in parasitic helminths. The crucial role played by GST in various chronic infections has been well reported. The dependence of nematodes on detoxification enzymes to maintain their survival within the host established the crucial role of GST in filariasis and other related diseases. Hence, this well-established role of GST in filariasis along with its greater nonhomology with its human counterpart makes it an important therapeutic drug target. Here in this study, we have tried to explore the inhibitory potential of some of the well-reported natural ant-filarial compounds against the GST from Wuchereria bancrofti (W.bancrofti) and Brugia malayi (B.malayi). In silico virtual screening, approach was used to screen the selected natural compounds against GST from W.bancrofti and B.malayi. On the basis of our results, here we are reporting some of the natural compounds which were found to be very effective against GSTs. Along with we have also revealed the characteristic of the active site of BmGST and WbGST and the role of important active site residues involve in the binding of natural compounds within the active site of GSTs. This information will oped doors for using natural compounds as anti-filarial therapy and will also be helpful for future drug discovery.

Keywords

Virtual screening Brugia malayi Wuchereria bancrofti Natural compounds.
Saeed, M., Imran, M., Baig, M. H., Kausar, M. A., Shahid, S., & Ahmad, I. (2018). Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti. Cellular and Molecular Biology, 64(13), 69–73. https://doi.org/10.14715/cmb/2018.64.13.13
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Author Biography

Irfan Ahmad, Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Khalid University. Abha, KSA
Assitant Professor
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