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Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer

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Adenovirus-mediated overexpression FADD induces a significant antitumor effect on human colorectal cancer cells both in vitro and in vivo

https://doi.org/10.14715/cmb/2018.64.6.6
Xueling He
Laboratory Animal Center of Sichuan University, Chengdu 610041, China
Xu Peng
Laboratory Animal Center of Sichuan University, Chengdu 610041, China
Yan Liu
Laboratory Animal Center of Sichuan University, Chengdu 610041, China
Xiaomei Zhang
Laboratory Animal Center of Sichuan University, Chengdu 610041, China
Hualing Li
Laboratory Animal Center of Sichuan University, Chengdu 610041, China
Hailin Yin
Laboratory Animal Center of Sichuan University, Chengdu 610041, China

Corresponding Author(s) : Xueling He

hxlscu@163.com

Cellular and Molecular Biology, Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer

Abstract

The Wnt/β-catenin signaling pathway plays important roles in cancers such as colorectal cancer. Colon cancer cells secrete and express high levels of β-catenin, which may stimulate autocrine signaling and further enhance activities of the canonical Wnt signaling pathway. Free β-catenin in the cytoplasm and nucleus leads to its association with T cell factor (TCF)/lymphocyte enhancing factor (Lef) transcription factors, and subsequent transcriptional activation of downstream target genes. FADD plays a key role in cellular apoptosis in many different types of cancer. Therefore, a recombinant adenovirus is constructed, in which an apoptosis gene FADD is placed under control of a promoter containing Tcf-responsive elements. It is observed that FADD overexpression can suppress cell growth and enhance apoptosis of SW480 cells in vitro. In addition, Ad-FADD can also suppress the growth of subcutaneous xenografts in the nude mice. Together, these results suggest that Ad-FADD has anti-proliferative and pro-apoptotic effects in colon cancer cells, which provides a novel strategy for treatment of colorectal cancer.

Keywords

Wnt/β-catenin Fas-associated death domain protein (FADD) Apoptosis Colon cancer.
He, X., Peng, X., Liu, Y., Zhang, X., Li, H., & Yin, H. (2018). Adenovirus-mediated overexpression FADD induces a significant antitumor effect on human colorectal cancer cells both in vitro and in vivo. Cellular and Molecular Biology, 64(6), 31–35. https://doi.org/10.14715/cmb/2018.64.6.6
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