The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Visfatin increases miR-21 to promote migration in HCC
Corresponding Author(s) : Yongjun Chen
water0033@163.com
Cellular and Molecular Biology,
Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer
Abstract
Hepatocellular carcinoma (HCC) is a common human malignancy. In this study, we aimed to investigate the serum levels of visfatin and miR-21 in HCC patients, to analysis the relationship between the pathological features and the plasma level of visfatin or miR-21, and to explore the roles of visfatin and miR-21 in migration of HCC cells. Our results showed that the serum levels of visfatin and miR-21 were significant higher in HCC patients than healthy subjects. The diagnostic sensitivity of serum visfatin was 82.5% and the specificity was 65.0%. The serum visfatin was significantly associated with the histology and metastasis. Visfatin induced miR-21 expression and cell migration in HepG2 cells. Transfection of miR-21 inhibitor suppressed the visfatin-induced migration in HCC cells. These results suggested that visfatin induced HCC cell migration via upregulation of miR-21, which provides a novel basis for the diagnosis of HCC.
Keywords
Visfatin
miR-21
HepG2
HCC
Metastasis.
Liang, N., Chen, Y., Yang, L., He, S., & Liu, T. (2018). Visfatin increases miR-21 to promote migration in HCC. Cellular and Molecular Biology, 64(6), 48–52. https://doi.org/10.14715/cmb/2018.64.6.9
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
