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Vol. 64 No. 7: Issue 7

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GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

https://doi.org/10.14715/cmb/2018.64.7.7
Yi-Hua Zhu
College of Life Sciences, Zhejiang University, Hangzhou, China
Zhen-Ming Pei
College of Life Sciences, Zhejiang University, Hangzhou, China

Corresponding Author(s) : Zhen-Ming Pei

nt1332@163.com

Cellular and Molecular Biology, Vol. 64 No. 7: Issue 7

Abstract

Heatstroke is still a potentially fatal threat during summer heat waves, despite improved prevention and treatment. It is reported that the transient receptor potential vanilloid 4 (TRPV4) inhibitor may protect septicemia mice. Many aspects of heatstroke have been defined, from the sepsis-mimic inflammatory response to hyperthermia. Hence, TRPV4 may be a therapeutic target for heatstroke. The results in murine models of heatstroke verified that GSK2193874, as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature, the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P<0.05). But GSK2193874 treatment before heat stress did not improve the symptoms of heatstroke mice. Therefore, TRPV4 should be involved in heatstroke-induced injury. Timely GSK2193874 administration may be useful to reduce heatstroke-induced injury. TRPV4 may be a potential new therapeutic target in fatal heatstroke.

Keywords

Heatstroke TRPV4 GSK2193874 Core temperature Coagulation indicator.
Zhu, Y.-H., & Pei, Z.-M. (2018). GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. Cellular and Molecular Biology, 64(7), 36–42. https://doi.org/10.14715/cmb/2018.64.7.7
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