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Vol. 64 No. 13: Issue 13

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Effect of boric acid on some elemental levels on rat's liver and kidney tissues during mercury chloride exposure

https://doi.org/10.14715/cmb/2018.64.13.16
Hurrem Turan Akkoyun
Department of Physiology, Faculty of Veterinary Science, Siirt University, Siirt, Turkey

Corresponding Author(s) : Hurrem Turan Akkoyun

turanakkoyun@hotmail.com

Cellular and Molecular Biology, Vol. 64 No. 13: Issue 13

Abstract

In this study, the effect of boric acid on the important trace elements copper (Cu), iron (Fe), zinc (Zn), manganese (Mn) and nickel (Ni) in liver and kidney tissue of rats treated with mercury chloride was investigated. Twenty-four male Wistar albino rats (weighing 200 ± 300 g) were divided into 3 groups: Control (C), Mercury chloride (HgCl2), Mercury chloride (HgCl2) + boric acid (BA). Iron and copper were decreased whereas Mn, Zn and Ni levels were increased in liver tissue in Hg administered group compared to control. Cu (p<0.01) and Mn (p<0.001) levels were increased in Hg + BA administered group compared to Hg group. Renal tissue Cu (p<0.01), Mn and Zn levels were increased whereas Ni (p<0.05) and Fe levels were decreased in Hg administered group compared to control group. Cu (p<0.001) and Zn (p<0.05) content increased in Hg + BA group compared to control group. As a result, it is thought that boric acid may have an effect on important trace element levels such as copper (Cu), iron (Fe), zinc (Zn), manganese (Mn), nickel (Ni) in case of oxidative stress caused by mercury chloride.

Keywords

Boric Acid Mercury Chloride Trace Elements Liver Kidney.
Akkoyun, H. T. (2018). Effect of boric acid on some elemental levels on rat’s liver and kidney tissues during mercury chloride exposure. Cellular and Molecular Biology, 64(13), 84–88. https://doi.org/10.14715/cmb/2018.64.13.16
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References
  1. Cummings N. Trace metals in the brain and Wilson's disease. J Clin Path. 1968,21:1-7.
  2. Ehmann WD, Markesbery W, Alauddin M, Hossain TIM, Brubaker EH. Brain trace elements in Alzheimer's disease.Neurotoxicology.1986,7:197-206.
  3. Farkas E, Scheibler H, Reffy A. Bezur L. Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease. Arch Gerontol Geriatr. 1995,21:89-97
  4. Kuriwaki J, Nishijo M, Honda R, et al. Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney. Toxicol Lett. 2005,156:369–376.
  5. Berthon G. Aluminum speciation in relation to aluminum bioavailability, metabolism and toxicity. Coord. Chem. Rev. 2002,228(2): 319–341.
  6. Good PF, Perl DP, Bierer LM, Schidler J. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Annals of Neurology. 1992,31(3): 286–292.
  7. Yokel RA. Brain uptake, retention, and efflux of aluminum and manganese. Environ Health Persp. 2002, 110 (5): 699–704.
  8. Agarwal R, Goel SK, Chandra R, Behari JR. Role of vitamin E in preventing acute mercury toxicity in rat. Environ. Toxicol. Phar. 2010,29,70–78.
  9. Rao MV, Chhunchha B. Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid. Food Chem. Toxicol. 2010, 48, 7–10.
  10. Sener G, Sehirli AO, Ayanoglu-Dulger G. Melatonin protects against mercury (II)-induced oxidative tissue damage in rats. Pharmacol Toxicol. 2003,93(6): 290–296.
  11. Piccoli C, D'Aprile A, Scrima R, Ambrosi L, Zefferino R, Capitanio N."Subcytotoxic mercury chloride inhibits gap junction intercellular communication by a redox- and phosphorylationmediated mechanism”, Free Radical Biol. Med. 2012,52: 916– 927.
  12. Zhang FS, Nriagu JO, Itoh H. "Mercury removal from water using activated carbons derived from organic sewage sludge”, Water Res. 2005,39: 389–395.
  13. Yavuz H, Denizli A, Gungunes H, Safarikova M, Safarik I. "Biosorption of mercury on magnetically modified yeast cells”, Sep. Purif. Technol. 2006,52: 253–260.
  14. Inbaraj BS, Wang JS, Lu JF, Siao FY, Chen BH. "Adsorption of toxic mercury(II) by an extracellular biopolymer poly(c-glutamic acid)”, Bioresource Technol. 2009,100(1): 200-207.
  15. Lund BO, Miller DM, Woods JS. Studies on Hg (II) induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem Pharmacol. 1993,45:2017–2024.
  16. Harisa GI, Alanazi FK, El-Bassat RA, Malik A, Abdallah GM. Protective effect of pravastatin against mercury induced vascular cells damage: Erythrocytes as surrogate markers. Environ Toxicol Pharmacol. 2012,34(2): 428–435.
  17. Murray FJ. A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol Trace Elem Res. 1998,66:331–341.
  18. Meacham SL, Taper LJ, Volpe SL. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environ Health Perspect. 1994,102:79–82.
  19. Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME. Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Experimental and therapeutic medicine.2015, 9(3), 1023-1027.
  20. Pawa S, Ali S. Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact. 2006,160: 89-98.
  21. Wang Q ,Yang X , Zhang B , Yang X ,Wang K. Cinnabar ć°s Different From Mercuric Chloride ć°n Mercury Absorption And Influence On The Brain Serotonin Level. Basic & Clinical Pharmacology & Toxicology. 2013, 112, 412–417.
  22. Colak S, Geyikoglu F, Keles ON, Türkez H, Topal A, Unal B.The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. Toxicol Ind Health. 2011,27(8):700-10.
  23. Souzaa SO, Pereiraa TRS, ívilaa DVL, Paixí£oa LB, Soaresb SAR, Queirozb AFS, Pessoaa AGG. , Korna MGA, Maranhí£oc TA, Araujo RGO. Optimization of sample preparation procedures for evaluation of the mineral composition of fish feeds using ICP-based methods. Food Chemistry. 2018,01.178
  24. Djinovic-Stojanovic JM, Nikolic DM, Vranic DV, Babic JA, Milijasevic MP, Pezo LL, Jankovic SD. Zinc and magnesium in different types of meat and meat products from the Serbian market. Journal of Food Composition and Analysis.2017, 59, 50-54.
  25. í‡iftçi H, í–zkaya A, Dayangaç A, í–lçücü A, í‡elć°k S, Șahin Z, AteÈ™ S. Effect of lipoic acid on the some elements in brain tissue of DMBA-induced Guinea Pigs. Kafkas íœniversitesi Veteriner Fakültesi Dergisi.2009,15(4), 569-573.
  26. Mohamad NS.Trace elements homeostatic imbalance in mild and severe psoriasis: a new insight in biomarker diagnostic value for psoriasis. Our Dermatol Online.2013, 4(4): 449-452).
  27. Seven G. Meme, Baş boyun ve Mide kanserli hastalarda Radyoterapi öncesi ve sonrası iz elementler ve ağır metal düzeylerinin (Zn, Cu, Pb, Cd, Mn, Mg ve Co) ve bazı biyokimyasal (katalaz ve karbonik anhidraz) parametrelerin incelenmesi. Yüzüncü Yıl íœniversitesi, Fen Bilimleri Enstitüsü, Kimya Anabilim Dalı, Biyokimya Bilim Dalı (yüksek lisans tezi), Van. 2010.
  28. Nielsen FH, Hunt JR. Trace elements emerging as important in human nutrition. In: P. J. Stumbo, (Ed.), Proceedings of the Fourteenth National Databank Conference, Iowa City: University of Iowa.1989,135-143.
  29. Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. The Cochrane Database of Systematic Reviews. 3: CD000980.2007.
  30. Gecit I, Kavak S, Demir H, Gunes M, Pirincci N, Cetin C, et al. Serum trace element levels in patients with bladder cancer. Asian Pac J Cancer Prev. 2011,12:3409-13.
  31. Sayır F, Kavak S, Meral I, Demir H, Cengiz N, Cobanoğlu U. Effects of crush and axotomy on oxidative stress and some trace element levels in phrenic nerve of rats. Brain Res Bull.2013, 92:84-8
  32. Al-Fartusie FS, Mohssan SN. Essential Trace Elements and Their Vital Roles in Human Body. Indian Journal of Advances in Chemical Science. 2017, 5(3),127-136
  33. Copper In: National Research Council, Food Nutrition Board, Recommended Dietary Allowances, Washington, DC: NRC/NAS,1980,151-154.
  34. Oto G, Ekin S, í‡elikezen Fí‡,Yener Z,Tanrıtanır P, í–zdemir H,Yıldırım S, Bayramoğlu M. Cytoprotective effects of boric acid and coenzyme Q10 therapy on induced pulmonary fibrosis in response to intratracheal administration of bleomycin in rats. Fresenius Environmental Bulletin. 2013, 22(8):2428-2434.
  35. Muto H, Shinada M, Tokuta K,Takizawa Y. Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis. Occupational and Environmental Medicine. 1991,48(6), 382-388.
  36. Gkouvatsos K, Papanikolaou G, Pantopoulos K. Regulation of iron transport and the role of transferrin.Biochim Biophys Acta. 2011,1820, 157-64.
  37. Lynch S. Case studies: iron. Am J Clin Nutr. 2011, 94, (2), 673-8.
  38. Feng W, Wang M, Li B, Liu J, Chai Z, Zhao J, Deng G. Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury. Toxicology letters.2004, 152(3), 223-234.
  39. Ansar S. Effect of selenium on the levels of cytokines and trace elements in toxin-mediated oxidative stress in male rats. Biological trace element research. 2016, 169(1), 129-133.
  40. Parkin DM, Bray F, Ferlay J, Pisani P Global cancer statistics,2002, CA Cancer J Clin.2005,55: 74–108
  41. Kasprzak KS. Nickel, advances in modern environ, Toxicology.1987,11:145-183.
  42. Welch RM. The biological significance of nickel, Journal of Plant Nutrition.1981,3(1-4): 345-356.
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