Pulicaria vulgaris Gaertn. essential oil: an alternative or complementary treatment for Leishmaniasis

Mehdi Sharifi-Rad; Bahar Salehi; Javad Sharifi-Rad; William N Setzer; Marcello Iriti

doi:10.14715/cmb/2018.64.8.3

Issue

Vol. 64 No. 8: Biosynthesis, metabolism and biological activities of natural products from medicinal and food plants

Issue Published : July 5, 2018

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Pulicaria vulgaris Gaertn. essential oil: an alternative or complementary treatment for Leishmaniasis

https://doi.org/10.14715/cmb/2018.64.8.3

Mehdi Sharifi-Rad

Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, Iran

Bahar Salehi

Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Javad Sharifi-Rad

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

William N Setzer

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

Marcello Iriti

Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy

Corresponding Author(s) : Javad Sharifi-Rad

javad.sharifirad@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 8: Biosynthesis, metabolism and biological activities of natural products from medicinal and food plants
Article Published : June 25, 2018

Abstract

Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates. The P. vulgaris EO was active against the promastigote forms of L. major and L. infantum, with IC50 values of 244.70 and 233.65 µg/mL, respectively. Pulicaria vulgaris EO may serve as an alternative or complementary treatment for leishmaniasis.

Keywords

Protozoal diseases Parasites Thymol Iranian plants.

Sharifi-Rad, M., Salehi, B., Sharifi-Rad, J., Setzer, W. N., & Iriti, M. (2018). Pulicaria vulgaris Gaertn. essential oil: an alternative or complementary treatment for Leishmaniasis. Cellular and Molecular Biology, 64(8), 18–21. https://doi.org/10.14715/cmb/2018.64.8.3