The correlation between infections by human papillomavirus types 6/11 and 16/18 and mammary gland hyperplasia with glandular thickening

Deng Xiaoqun; Long Xiaoli; Li Jun; Xiaojuan Yang

doi:10.14715/cmb/2019.65.5.8

Issue

Vol. 65 No. 5: Issue 5

Issue Published : July 13, 2019

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The correlation between infections by human papillomavirus types 6/11 and 16/18 and mammary gland hyperplasia with glandular thickening

https://doi.org/10.14715/cmb/2019.65.5.8

Deng Xiaoqun

Department of the First people's Hospital of Lanzhou City, 1th Wu Jia Yuan West Street of Qi Li He District in Lanzhou City, Gansu,730050 China

Long Xiaoli

Department of the First people's Hospital of Lanzhou City, 1th Wu Jia Yuan West Street of Qi Li He District in Lanzhou City, Gansu,730050 China

Li Jun

Department of the First people's Hospital of Lanzhou City, 1th Wu Jia Yuan West Street of Qi Li He District in Lanzhou City, Gansu,730050 China

Xiaojuan Yang

Department of the First people's Hospital of Lanzhou City, 1th Wu Jia Yuan West Street of Qi Li He District in Lanzhou City, Gansu,730050 China

Corresponding Author(s) : Xiaojuan Yang

ktuj80@163.com

Cellular and Molecular Biology, Vol. 65 No. 5: Issue 5
Article Published : June 30, 2019

Abstract

The aim of the present study was to investigate the correlation between human papillomavirus (HPV) type 6/11 and 16/18 infections and glandular thickening mammary gland hyperplasia in order to explore methods for preventing glandular thickening mammary gland hyperplasia. A total of 240 patients with glandular thickening mammary gland hyperplasia who were treated by surgery in our hospital from January 2012 to June 2017 were enrolled in the present study. The hyperplastic breast tissue and adjacent normal breast tissue were taken to test HPV type 6/11 and 16/18 infections using conventional PCR and in situ hybridization techniques. The correlations between HPV type 6/11 and 16/18 infections and glandular thickening mammary gland hyperplasia were analyzed using statistical methods of chi-square test. The infection rates of HPV type 6/11 and 16/18 in the hyperplastic breast tissue were 31.95% and 34.91%, respectively and 11.83% and 14.79% in the normal breast tissue, respectively. The differences were statistically significant (all p<0.05). HPV type 6/11 and 16/18 infections may be closely related to the development of glandular thickening mammary gland hyperplasia, and may be one of the causes of glandular thickening mammary gland hyperplasia.

Keywords

Human papillomavirus HPV 6/11 HPV 16/18 Glandular thickening mammary gland hyperplasia.

Xiaoqun, D., Xiaoli, L., Jun, L., & Yang, X. (2019). The correlation between infections by human papillomavirus types 6/11 and 16/18 and mammary gland hyperplasia with glandular thickening. Cellular and Molecular Biology, 65(5), 49–53. https://doi.org/10.14715/cmb/2019.65.5.8

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References

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Salamat F, Niakan B, Keshtkar A, Rafiei E, Zendehdel M. Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses. Iran J Med Sci 2018; 43: 355-364.
Wu Y, Lin Y, Lian Y, Lin P, Wang S, Fu F, et al. Identifying Two Common Types of Breast Benign Diseases Based on Multiphoton Microscopy. Scanning 2018; 2018: 3697063.
Kong CS, Welton ML, Longacre TA. Role of human papillomavirus in squamous cell metaplasia carcinoma of the rectum. Am J Surg Pathol 2007; 31: 919-925.
Gupta S, Kumar P, Das BC. HPV: Molecular pathways and targets. Curr Probl Cancer 2018; 42: 161-174.
Chien CY, Su CY, Fang FM, Huang HY, Chuang HC, Chen CM, et al. Lower prevalence but favorable survival for human papillomavirus-related squamous cell carcinoma of tonsil in Taiwan. Oral Oncol 2008; 44: 174-179.
Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.
Hammer A, Rositch A, Qeadan F, Gravitt PE, Blaakaer J. Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis. Int J Cancer 2016; 138: 2795-2803.
Steben M, Garland SM. Genital warts. Best Pract Res Clin Obstet Gynaecol 2014; 28: 1063-1073.
Huang PH, Zhan XE, Liu FX. [Preliminary study on the evolution mechanism of sex hormone receptors in benign and malignant breast diseases]. Tumor Prev Res 1989; 3: 219-223.
Brooks PG. The relationship of estrogen and progesterone to breast disease. J Reprod Med 1984; 29: 530-538.
Eide ML, Debaque H. HPV detection methods and genotyping techniques in screening for cervical cancer. Ann Pathol 2012; 32: 15-23.
Kuo YB, Li YS, Chan EC. Rapid identification of HPV 16 and 18 by multiplex nested PCR-immunochromatographic test. J Virol Methods 2015; 212: 8-11.
Zaravinos A, Mammas IN, Sourvinos G, Spandidos DA. Molecular detection methods of human papillomavirus (HPV). Int J Biol Markers 2009; 24: 215-222.
Widschwendter A, Brunhuber T, Wiedemair A, Mueller-Holzner E, Marth C. Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history. J Clin Virol 2004; 31: 292-297.
Lawson JS, Heng B. Viruses and breast cancer. Cancers (Basel) 2010; 2: 752-772.
Akhter J, Aziz MAA, Al Ajlan A, Tulbah A, Akhtar M. Breast cancer: Is there a viral connection? Adv Anat Pathol 2014; 21: 373-381.
Gopalkrishna V, Singh U, Sodhani P, Sharma JK, Hedau ST, Mandal AK, et al. Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction. Breast Cancer Res Treat 1996; 39: 197-202.
Lindel K, Forster A, Altermatt HJ, Greiner R, Gruber G. Breast cancer and human papillomavirus (HPV) infection: No evidence of a viral etiology in a group of Swiss women. Breast 2007; 16: 172-177.
Hedau S, Kumar U, Hussain S, Shukla S, Pande S, Jain N, et al. Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. BMC Cancer 2011; 11: 27.
Chang P, Wang T, Yao Q, Lv Y, Zhang J, Guo W, et al. Absence of human papillomavirus in patients with breast cancer in north-west China. Med Oncol 2012; 29: 521-525.

References

Tice JA, O'Meara ES, Weaver DL, Vachon C, Ballard-Barbash R, Kerlikowske K. Benign breast disease, mammographic breast density, and the risk of breast cancer. J Natl Cancer Inst 2013; 105: 1043-1049.

Salamat F, Niakan B, Keshtkar A, Rafiei E, Zendehdel M. Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses. Iran J Med Sci 2018; 43: 355-364.

Wu Y, Lin Y, Lian Y, Lin P, Wang S, Fu F, et al. Identifying Two Common Types of Breast Benign Diseases Based on Multiphoton Microscopy. Scanning 2018; 2018: 3697063.

Kong CS, Welton ML, Longacre TA. Role of human papillomavirus in squamous cell metaplasia carcinoma of the rectum. Am J Surg Pathol 2007; 31: 919-925.

Gupta S, Kumar P, Das BC. HPV: Molecular pathways and targets. Curr Probl Cancer 2018; 42: 161-174.

Chien CY, Su CY, Fang FM, Huang HY, Chuang HC, Chen CM, et al. Lower prevalence but favorable survival for human papillomavirus-related squamous cell carcinoma of tonsil in Taiwan. Oral Oncol 2008; 44: 174-179.

Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.

Hammer A, Rositch A, Qeadan F, Gravitt PE, Blaakaer J. Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis. Int J Cancer 2016; 138: 2795-2803.

Steben M, Garland SM. Genital warts. Best Pract Res Clin Obstet Gynaecol 2014; 28: 1063-1073.

Huang PH, Zhan XE, Liu FX. [Preliminary study on the evolution mechanism of sex hormone receptors in benign and malignant breast diseases]. Tumor Prev Res 1989; 3: 219-223.

Brooks PG. The relationship of estrogen and progesterone to breast disease. J Reprod Med 1984; 29: 530-538.

Eide ML, Debaque H. HPV detection methods and genotyping techniques in screening for cervical cancer. Ann Pathol 2012; 32: 15-23.

Kuo YB, Li YS, Chan EC. Rapid identification of HPV 16 and 18 by multiplex nested PCR-immunochromatographic test. J Virol Methods 2015; 212: 8-11.

Zaravinos A, Mammas IN, Sourvinos G, Spandidos DA. Molecular detection methods of human papillomavirus (HPV). Int J Biol Markers 2009; 24: 215-222.

Widschwendter A, Brunhuber T, Wiedemair A, Mueller-Holzner E, Marth C. Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history. J Clin Virol 2004; 31: 292-297.

Lawson JS, Heng B. Viruses and breast cancer. Cancers (Basel) 2010; 2: 752-772.

Akhter J, Aziz MAA, Al Ajlan A, Tulbah A, Akhtar M. Breast cancer: Is there a viral connection? Adv Anat Pathol 2014; 21: 373-381.

Gopalkrishna V, Singh U, Sodhani P, Sharma JK, Hedau ST, Mandal AK, et al. Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction. Breast Cancer Res Treat 1996; 39: 197-202.

Lindel K, Forster A, Altermatt HJ, Greiner R, Gruber G. Breast cancer and human papillomavirus (HPV) infection: No evidence of a viral etiology in a group of Swiss women. Breast 2007; 16: 172-177.

Hedau S, Kumar U, Hussain S, Shukla S, Pande S, Jain N, et al. Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. BMC Cancer 2011; 11: 27.

Chang P, Wang T, Yao Q, Lv Y, Zhang J, Guo W, et al. Absence of human papillomavirus in patients with breast cancer in north-west China. Med Oncol 2012; 29: 521-525.

Author biographies is not available.