Issue

Vol. 66 No. 2: Issue 2

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Atypical extraventricular neurocytoma: A case report

https://doi.org/10.14715/cmb/2020.66.2.25
Peng Zhang
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Cui-Ying Wu
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Jia-Zhen Qin
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Ru-Xiang Xu
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Miao-Chun Bai
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Lu-Ping Wang
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Yi-Wu Dai
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China
Xue-Zhen Li
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Corresponding Author(s) : Yi-Wu Dai

uzdgc3@163.com

Cellular and Molecular Biology, Vol. 66 No. 2: Issue 2

Abstract

Atypical extraventricular neurocytoma (EVN) is a rare condition characterized by diffuse tumor cell hyperplasia, increased neovascularization, increased necrosis, and aggressive characteristics. A case of a 25-year old man who presented with atypical EVN in his left parietal - occipital flaps is reported. Magnetic resonance imaging (MRI) revealed a well-defined globular mass with heterogeneous signals in the left parietal lobe, and mild perilesional edema. After left parietal craniotomy and tumor excision, pathologic examination of the resected tissue revealed that the lesion was localized mainly in the white matter and imbued with tumor cells possessing round hyperchromatic nuclei with perinuclear halos and increased microvascular proliferation. The patient underwent radiotherapy at 21st postoperative day. Over the past 26 months, the patient has been regularly followed up, and so far no neurologic deficits have been observed. The latest MRI showed that the tumor bed was stable with slight peritumoral edema. The results of clinical, histopathological and immunohistochemical examinations indicate that atypical EVN is a rare neoplasm with unique radiographic and pathologic characteristics. It possesses more aggressive properties than typical EVN.

Keywords

Extraventricular neurocytoma Central neurocytomas Left parietal craniotomy Magnetic resonance imaging Intensity modulated radiotherapy.
Zhang, P., Wu, C.-Y., Qin, J.-Z., Xu, R.-X., Bai, M.-C., Wang, L.-P., Dai, Y.-W., & Li, X.-Z. (2020). Atypical extraventricular neurocytoma: A case report. Cellular and Molecular Biology, 66(2), 153–156. https://doi.org/10.14715/cmb/2020.66.2.25
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Rousseau A, Mokhtari K, Duyckaerts C. The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol 2008; 21: 720-727.
  2. Brat DJ, Scheithauer BW, Eberhart CG, Burger PC. Extraventricular neurocytomas: pathologic features and clinical outcome. Am J Surg Pathol 2001; 25: 1252-1260.
  3. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016; 131: 803-820.
  4. Choudhari KA, Kaliaperumal C, Jain A, Sarkar C, Soo MY, Rades D, et al. Central neurocytoma: a multi-disciplinary review. Br J Neurosurg 2009; 23: 585-595.
  5. Sharma MC, Deb P, Sharma S, Sarkar C. Neurocytoma: a comprehensive review. Neurosurg Rev 2006; 29: 270-285.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 1042 Download : 405