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Vol. 67 No. 2: Issue 2

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Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

https://doi.org/10.14715/cmb/2021.67.2.6
Zeeshan Javed
Office of Research Innovation and Commercialization Department, Lahore Garrison University, Lahore, Pakistan
Khushbukhat Khan
Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12, Islamabad 44000, Pakistan
Qamar Raza
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Haleema Sadia
Department of biotechnology BUITEMS, Quetta, Pakistan
Faiez Ahmad Shah
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan
Touqeer Ahmad
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Angela Bentivegna
School of Medicine and Surgery, University of Milano-Bicocca Via Cadore, 48 - 20900 Monza (MB) Italy
Riccardo Bazzoni
Stem Cell Research Laboratory, Department of Medicine, University of Verona, Pz.leScuro 10, 37134 Verona, Italy
William N. Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Mohammed M Alshehri
Department of Pharmaceutical Care Services, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
Javad Sharifi-Rad
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sevgi Durna Daştan
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140, Sivas, Turkey

Corresponding Author(s) : Javad Sharifi-Rad

javad.sharifirad@gmail.com

Cellular and Molecular Biology, Vol. 67 No. 2: Issue 2

Abstract

Notch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates process of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are being orchestrated by the Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive role in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in development of nervous system and how this versatile pathway interplay with microRNAs in glioblastoma. This review sheds light on interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by the Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.

Keywords

notch signaling miRNAs glioblastoma tumorigenesis therapeutics
Javed, Z., Khan, K., Raza, Q., Sadia, H., Ahmad Shah, F., Ahmad, T., Bentivegna, A., Bazzoni, R., Setzer, W. N. ., Alshehri, M. M. ., Sharifi-Rad, J., & Daştan, S. D. . (2021). Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas. Cellular and Molecular Biology, 67(2), 33–43. https://doi.org/10.14715/cmb/2021.67.2.6
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