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Vol. 66 No. 7: Issue 7

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Analysis of topological properties and drug discovery for bipolar disorder and associated diseases: A bioinformatics approach

https://doi.org/10.14715/cmb/2020.66.7.23
Khairul Alam Shadhin
Department of Software Engineering, Daffodil International University, Sukrabad, Dhanmondi, Dhaka, Bangladesh
Md. Rakibul Hasan
Department of Software Engineering, Daffodil International University, Sukrabad, Dhanmondi, Dhaka, Bangladesh
Bikash Kumar Paul
Department of Software Engineering, Daffodil International University, Sukrabad, Dhanmondi, Dhaka, Bangladesh
Kawsar Ahmed
2Department of Information and Communication Technology (ICT), Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail, 1902, Bangladesh.
Mohammad Ali Moni
WHO Collaborating Centre on eHealth, School of Public Health and Community Medicine, Faculty of Medicine, UNSW Sydney, Australia
Danial Kahrizi
Touhid Bhuyian
Department of Software Engineering, Daffodil International University, Sukrabad, Dhanmondi, Dhaka, Bangladesh
Sobhy M. Ibrahim
Department of Biochemistry, College of Science, King Saud University, P.O. Box: 2455, Riyadh 11451, Saudi Arabia

Corresponding Author(s) : Danial Kahrizi

d.kahrizi@cellmolbiol.org

Cellular and Molecular Biology, Vol. 66 No. 7: Issue 7

Abstract

With the advancement and development of sophisticated bioinformatics tools, the area of computational bioinformatics and systems biology analysis is expanding day by day. The bipolar or manic-depressive disorder might be characterized as one of the most crippling mental problems that affect the people of early age and grown-ups. The objective of the present study was to investigate the association between genetic mutations in the four above listed diseases and to create a Protein-protein interaction (PPI) network or common pathways. Firstly, we need to find out the genetic relationship between them. Thus it will help us to understand the genetic association between them and help to develop the drug design for all the diseases. Genes responsible for these diseases are gathered, pre-processed, processed and mining using python scripts. This exploration is expected to carry out further measurements in the field of drug structure and also contributes to the biological and biomedical sectors.

Keywords

Bioinformatics Bipolar Disorders Schizophrenia Coronary Heart Diseases Stroke Genetic Association PPI network Clustering Gene Regulatory network PDI network PCI network
Shadhin, K. A., Hasan, M. R., Paul, B. K., Ahmed, K., Moni, M. A., Kahrizi, D., Bhuyian, T., & Ibrahim, S. M. (2020). Analysis of topological properties and drug discovery for bipolar disorder and associated diseases: A bioinformatics approach. Cellular and Molecular Biology, 66(7), 152–160. https://doi.org/10.14715/cmb/2020.66.7.23
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