MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells

Wang  Zhi; Qu  Feng; Zhang  Mingzhu

doi:10.14715/cmb/2022.68.1.18

Issue

Vol. 68 No. 1: Issue 1

Issue Published : May 22, 2022

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MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells

https://doi.org/10.14715/cmb/2022.68.1.18

Wang Zhi

Foot and Ankle Surgery Center, Beijing Tongren Hospital of Capital Medical University, Beijing 100005, China

Qu Feng

Foot and Ankle Surgery Center, Beijing Tongren Hospital of Capital Medical University, Beijing 100005, China

Zhang Mingzhu

Foot and Ankle Surgery Center, Beijing Tongren Hospital of Capital Medical University, Beijing 100005, China

Corresponding Author(s) : Zhang Mingzhu

michaelzhang120@hotmail.com

Cellular and Molecular Biology, Vol. 68 No. 1: Issue 1
Article Published : May 22, 2022

Abstract

MicroRNAs (miRNAs) have been documented to function differently in numerous human cancers. Our study planned to investigate the role of microRNA-140 (miR-140) and to identify its possible target in osteosarcoma (OS) to predict their mechanism in OS. The miR-140 was down-regulated in OS, and its high expression decreased MG63 cell proliferation. At the molecular level, Wnt1 was a target of miR-140, and its expression could be suppressed by miR-140. Besides, miR-140 overexpression decreased drug resistance in OS cells treated by doxorubicin. Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/β-catenin signaling.

Zhi, W. ., Feng, Q. ., & Mingzhu, Z. . (2022). MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells. Cellular and Molecular Biology, 68(1), 140–146. https://doi.org/10.14715/cmb/2022.68.1.18