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Copyright (c) 2022 Xu Wang, Lili Dai, Jing Liu, Jing Ge
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Expression of miR-128-3p, miR-193a-3p and miR-193a-5p in endometrial cancer tissues and their relationship with clinicopathological parameters
Corresponding Author(s) : Jing Ge
Cellular and Molecular Biology,
Vol. 68 No. 8: Issue 8
Abstract
In order to explore the expression of microRNA-128-3p (miR-128-3p), microRNA-193a-3p (miR-193a-3p) and microRNA-193a-5p (miR-193a-5p) in the endometrial carcinoma and their relationship with clinicopathological parameters, the post-operative clinical samples of 61 endometrial cancer patients who underwent surgical resection in our hospital from February 2019 to February 2022 were collected as cancer tissues. The post-operative clinical samples of 61 normal endometrium patients who underwent surgical resection due to non-tumor diseases in our hospital were collected as para cancer tissues. miR-128-3p, miR-193a-3p and miR-193a-5p were measured by fluorescence quantitative polymerase, and the relationship between them and clinicopathological parameters and the correlation among them were analyzed. Results showed that miR-128-3p, miR-193a-3p and miR-193a-5p were lower in cancer tissues than in adjacent tissues (P<0.05). miR-128-3p, miR-193a-3p and miR-193a-5p were not related to the age and histopathological type of endometrial cancer patients (P>0.05). Still, they were related to FIGO stage, degree of differentiation, depth of myometrial invasion, lymph node metastasis and distant metastasis (P<0.05), and compared with FIGO stage I-II, medium and high differentiation, depth of myometrial invasion<1/2, no lymph node metastasis and no distant metastasis, FIGO stage III-IV, low differentiation miR-128-3p, miR-193a-3p and miR-193a-5p were lower in endometrial cancer patients with myometrial invasion depth≥1/2, lymph node metastasis and distant metastasis (P<0.05). miR-128-3p, miR-193a-3p and miR-193a-5p were the risk factors of endometrial carcinoma (P<0.05). miR-128-3p and miR-193a-3p were positively correlated (r = 0.423, P = 0.001); miR-128-3p and miR-193a-5p were positively correlated (r = 0.342, P = 0.007); miR-193a-3p and miR-193a-5p were positively correlated (r = 0.555, P = 0.001). miR-128-3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients. They are expected to become potential prognostic markers and therapeutic targets of the disease.
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