Mohamd Abd  Ellatif; Basiouny El Gamal; Adel Osman  Musaam; Arshi Malik; Mohammed  Tarique

doi:10.14715/cmb/2023.69.2.1

Issue

Vol. 69 No. 2: Issue 2

Issue Published : May 24, 2023

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An Update on Genetic Predisposition for Prostate Cancer: Perspectives and Prospects

Genetic Predisposition for Prostate Cancer

https://doi.org/10.14715/cmb/2023.69.2.1

Mohamd Abd Ellatif

Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia

Basiouny El Gamal

Department of Pathology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia

Adel Osman Musaam

Department Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Arshi Malik

Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia

Mohammed Tarique

Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India

Corresponding Author(s) : Mohammed Tarique

tariquejamiacirbsc@gmail.com

Cellular and Molecular Biology, Vol. 69 No. 2: Issue 2
Article Published : February 28, 2023

Abstract

Prostate cancer (PC) is a heterogeneous disease that kills a significant number of people all over the world. It is the most common cancer in men, especially in the western world, and causes morbidity and mortality. There are several important risk factors known for PC like age, ethnicity, and inherited genetic variants which contribute significantly. The current research studies are endeavoring to identify genetic markers for PC and to understand underlying molecular mechanisms, so that new diagnostic and screening tests based on genetics can be developed for PC. The present review discusses candidate genes such as HOXB13, BRCA1, BRCA2, ATM, MMR gene, RAD51C, CHECK2, etc., and family-based linkage studies which defined the location of loci on chromosomal regions like 1q24-25, 1q42-43, Xq27-28, 1p36, 20q13, 17q21. Furthermore, the major part of the review focuses on important PC susceptible loci (8q24, 10q11, 17q12, 17q24, and 19q13, etc.) and risk variants identified by population-based genome-wide association studies (GWAS).

Keywords

Prostate cancer, genome-wide association study (GWAS), genetic variants, susceptible loci

Ellatif, M. A. ., Gamal, B. E., Musaam, A. O. ., Malik, A., & Tarique, M. . (2023). An Update on Genetic Predisposition for Prostate Cancer: Perspectives and Prospects: Genetic Predisposition for Prostate Cancer. Cellular and Molecular Biology, 69(2), 1–7. https://doi.org/10.14715/cmb/2023.69.2.1