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Copyright (c) 2023 Tao Zhang, Ning Zhang, Xiao Wu, Cheng Chen, Lingling Wang, Ting Bai, Tao Peng
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Effect of Microecological Regulator Combined with Enteral Nutrition on Immune and Coagulation Function in Patients with Chronic Critical Illness
Corresponding Author(s) : Tao Peng
Cellular and Molecular Biology,
Vol. 69 No. 2: Issue 2
Abstract
This study was to investigate the effect of microecological regulators combined with enteral nutrition on immune and coagulation function in patients with a chronic critical illness. For this purpose, 78 patients with chronic critical illness in our hospital from January 2020 to January 2022 were divided into study and control groups according to a simple random number table, with 39 cases in each group. The control group was given enteral nutrition support, and the study group was given a microecological regulator. The variables of the study were the intervention effects [albumin (ALB), prealbumin (PA), serum total protein (TP)], immune function (CD3+, CD4+, CD4+/CD8+), coagulation function [platelet count (PLT), Fibrinogen (FIB), prothrombin time (PT) and the incidence of complications. Results showed that Before the intervention, ALB (30.69 ± 3.66) G/L, PA (132.91 ± 18.04) mg/L, TP (55.65 ± 5.42) G/L in the study group and ALB (31.78 ± 4.24) TP (57.01 ± 5.13) G/L had no significant difference (P>0.05). After the intervention, the levels of ALB, PA and TP in the two groups were higher than those before the intervention. ALB (38.91 ± 3.54) G/L, PA (204.24 ± 28.80) mg/L and TP (69.75 ± 7.48) G/L in the study group were higher than those in the control group (ALB 34.83 ± 3.82) TP (62.70 ± 6.33) g/L (P<0.05). There was no significant difference between CD4+/CD8+ (1.31 ± 0.39) (P>0.05). After the intervention, the levels of CD3+, CD4+, CD4 and CD8 in the two groups were higher than those before the intervention. CD3+, CD4+ and CD4+/CD8+ were higher than that of the control group. in the study group PLT (226.57 ± 41.15) × 109/L, FIB (3.58 ± 1.09) G/L, PT (9.41 ± 0.82) s were recoeded. There was no significant difference between FIB (3.71 ± 1.13) G/L and PT (9.24 ± 0.77) s (P>0.05). After the intervention, PLT and FIB decreased and PT increased in both groups. PLT (177.15 ± 12.51) × 109/L and FIB (2.57 ± 0.39) G/L in the study group were lower than PLT (198.54 ± 10.77) × 109/L and FIB (3.04 ± 0.54) PT (15.79 ± 1.21) s was higher than PT (13.13 ± 1.33) s in the control group (P<0.05). The incidence of complications in the study group (5.13%) was lower than that in the control group (20.51%) (P<0.05). The conclusion was that the intervention effect of microecological regulators combined with enteral nutrition on patients with chronic critical illness is significant, which can improve their nutritional status and immune function, improve coagulation function, and reduce the incidence of complications.
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