Yanyan Yang; Xia Lu; Xiaoli Sun; Min Li; Ayinigeer Mierzhati; Huazhang Li

doi:10.14715/cmb/2023.69.7.31

Issue

Vol. 69 No. 7: Issue 7

Issue Published : September 13, 2023

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Study on the correlation of the TLR4/MyD88 axis with the degree of inflammatory response in patients with synovitis of the knee joint

Association of TLR4/MyD88 with knee synovitis

https://doi.org/10.14715/cmb/2023.69.7.31

Yanyan Yang

Department of Pathology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China

Xia Lu

Department of Obstetrics & Gynaecology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China

Xiaoli Sun

Department of Blood Transfusion, Xinjiang Military General Hospital, Urumqi, Xinjiang,830000, China

Min Li

Department of Endocrinology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang,830000, China

Ayinigeer Mierzhati

Department of Pathology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China

Huazhang Li

Department of Chinese Medicine, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang,830000, China

Corresponding Author(s) : Huazhang Li

13669985327@163.com

Cellular and Molecular Biology, Vol. 69 No. 7: Issue 7
Article Published : July 31, 2023

Abstract

This work aims to provide a novel reference for future diagnosis and treatment of synovitis of the knee joint (SKJ) by analyzing the correlation of the TLR4/MyD88 axis with the degree of inflammatory response in SKJ patients. First, this study retrospectively analyzed the clinical data of 46 SKJ patients (research group, RG) treated in our hospital from January 2021 to December 2022 and 52 concurrent healthy controls (control group, CG). Concentrations of TLR4, MyD88 and inflammatory factors (IFs) in peripheral blood were measured, and differences in TLR4 and MyD88 between groups were observed to explore the diagnostic performance of the two for SKJ. Additionally, the correlation of TLR4 and MyD88 with IFs and Western Ontario Mac Master (WOMAC) scores in SKJ patients was discussed. Through the above experiment, we found that TLR4 and MyD88 presented higher mRNA levels in RG than in CG (P<0.05), both of which had excellent diagnostic efficiency for SKJ. Pearson correlation coefficients identified a positive correlation of TLR4 and MyD88 mRNA with IFs and WOMAC scores (P<0.05). Therefore, The TLR4/MyD88 axis is activated in SKJ patients and is strongly related to the intensification of inflammatory responses.

Keywords

TLR4/MyD88 signaling pathway Synovitis of the Knee Joint Inflammatory response WOMAC score Correlation

Yang, Y., Lu, X., Sun, X., Li, M., Mierzhati, A., & Li, H. (2023). Study on the correlation of the TLR4/MyD88 axis with the degree of inflammatory response in patients with synovitis of the knee joint: Association of TLR4/MyD88 with knee synovitis. Cellular and Molecular Biology, 69(7), 191–195. https://doi.org/10.14715/cmb/2023.69.7.31