Wesam H.  Abdulaal; Nawal Helmi; Amal Hamza; Neveen A. Salem

doi:10.14715/cmb/2024.70.1.3

Issue

Vol. 70 No. 1: Issue 1

Issue Published : February 19, 2024

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Cerium oxide nanoparticles impact on sepsis-induced cerebral injury: Deciphering miRNA / NF-κB/TLR signalling pathway

CeO2 NPs impact on sepsis-induced cerebral injury

https://doi.org/10.14715/cmb/2024.70.1.3

Wesam H. Abdulaal

Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Nawal Helmi

Department of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia

Amal Hamza

Department of Biochemistry and Nutrition, Faculty of Women, Ain Shams University, Cairo, Egypt

Neveen A. Salem

Department of Narcotics, Ergogenics and Poisons, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt

Corresponding Author(s) : Neveen A. Salem

drneveensalem@gmail.com

Cellular and Molecular Biology, Vol. 70 No. 1: Issue 1
Article Published : January 31, 2024

Abstract

Sepsis is regarded as an inflammatory syndrome that consists of complex biochemical and pathophysiological dysregulation, brought on by endogenous factors in response to systemic infection. Sepsis can cause short- and long-term cerebral injury. Cerium oxide nanoparticles (CeO₂ NPs) have been reported to possess both anti-inflammatory and antioxidative properties. The current study investigated the potential role of cerium oxide nanoparticles in the management of sepsis-induced brain injury. To achieve this target, forty male albino rats were divided into 4 groups, ten rats each. Group (i) set as a shame group. Group (ii) set as shame group administrated CeO2 NPs. Group (iii) septic group treated with saline and Group (iv) septic group treated with CeO2 NPs. The sepsis model in rats was induced by cecal ligation and puncture (CLP). Results showed CeO2 NPs administration resulted in significant improvement in the survival rate of rats, suppression in serum sepsis biomarkers (CRP, ESM-1, PCT and D- dimer), amelioration of brain inflammatory mediators (TNF-α- IL-6, NF-kB and LTB4) as well as apoptotic markers (Cas-3 and BAX). Furthermore, immunomodulation of miRNAs expression (155,124 and 146a). These findings demonstrate a promising pivotal role of CeO2 NPs treatment in alleviating the deleterious effects induced by sepsis in the brain

Keywords

Sepsis Cecal ligation Inflammatory mediators

Abdulaal, W. H. ., Helmi, N., Hamza, A., & Salem, N. A. (2024). Cerium oxide nanoparticles impact on sepsis-induced cerebral injury: Deciphering miRNA / NF-κB/TLR signalling pathway: CeO2 NPs impact on sepsis-induced cerebral injury. Cellular and Molecular Biology, 70(1), 19–27. https://doi.org/10.14715/cmb/2024.70.1.3