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Copyright (c) 2024 Nezar Boreak Nezar Boreak, Noor Eissa Mousa Jaferi, Mohammed bashery , Hanan salem otudi, Abdullah Saad Almuqbil , Hisham Abushaqqaf, Sarah Mohammed Jurebi, Rana Qasem Wasly, Abdulaziz Ali alshahrani , Hadya Alkam , Hussam Almalki, Salwa Ahmad Hakami
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Harnessing the antimicrobial potential of Aegle marmelos against Mfa1 fimbriae in Porphyromonas gingivalis: a new strategy for endodontic therapy
Corresponding Author(s) : Nezar Boreak
Cellular and Molecular Biology,
Vol. 71 No. 1: Issue 1
Abstract
Endodontic infections, primarily caused due to microbial invasion into the root canal system, pose a significant challenge to dental health and management due to their complex etiology and resistance to conventional treatment. Porphyromonas gingivalis is a key bacterium pathogen that uses the Mfa1 fimbriae for its adhesion and biofilm formation contributing to its pathogenicity. The study explores the potential of Aegle marmelos leaf metabolites as a potential inhibitor of Mfa1 fimbriae using the molecular docking and simulation approach. We assessed the binding affinities of various metabolites with Rutin emerging as a promising candidate due to its strong and stable interactions within the Mfa1 active sites. The findings are also supported by existing literature that underscores the anti-microbial and anti-inflammatory properties of Aegle marmelos and its phytochemicals. The study also highlights the novelty of targeting Mfa1 fimbriae, a structure not addressed by current therapeutics.
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