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Copyright (c) 2024 Aishah E Albalawi, Waheeb S. Aggad, Fawiziah Khalaf Rashed Alharbi, Rawabi Mohamed almuhimed, Zamzam Alhuwaymil, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Reem Hasaballah Alhasani, Ifat Alsharif, Nouf S. Al-Abbas, Nehad. A Shaer, Charalampos Mavromatis, Mona H. Soliman
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Comparative renoprotective effect of Tamarix dioica leaf extracts and metformin against acetaminophen-induced renal toxicity in Swiss albino mice: Novel insights on renoprotection and therapeutic potential
Corresponding Author(s) : Mona H. Soliman
Cellular and Molecular Biology,
Vol. 71 No. 2: Issue 2
Abstract
Nephrotoxicity is characterized by the adverse effects on kidney function caused by various substances, including hazardous chemicals and drugs. This study aimed to investigate the neuroprotective properties of aqueous, methanolic, and ethanolic extracts of Tamarix dioica leaf against acetaminophen-induced kidney damage and compare their efficacy with metformin, a known neuroprotective agent. Thirty-six albino mice were randomly divided into six groups, including a standard control group, an acetaminophen-toxified group, a positive control group treated with metformin (at a dose of 200 mg/kg body weight), and three experimental groups treated with aqueous, methanolic, and ethanolic T. dioica extracts (at a dose of 400 mg/kg body weight each). The neuroprotective potential of the T. dioica extracts was assessed by evaluating hematological markers, electrolyte levels (Na+, K+, Cl-), antioxidant enzymes (CAT, SOD, MDA), renal function tests (urea and creatinine), and toxicity markers (SGOT and SGPT). Additionally, histopathological analysis was conducted to observe any pathological changes in kidney tissues stained with hematoxylin and eosin. The results demonstrated that the T. dioica leaf extracts effectively restored all the indicators and antioxidant enzyme levels to normal, significantly differing from the elevated levels observed in the acetaminophen control group (p < 0.05). Furthermore, histopathological examination revealed regeneration of glomeruli and renal tubules in the stained tissues. These findings suggest that T. dioica leaf extracts can potentially mitigate acetaminophen-induced nephrotoxicity.
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