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Copyright (c) 2025 Ahlam T. Bdaiwi, Aseel M. Yousif , Ban F. AL Drobie , Suhair W. Abbood Al-Osaighari
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Tumor-infiltrating CD20+ B lymphocyte: evaluation and association with clinical and pathological characteristics in oral squamous cell carcinoma
Corresponding Author(s) : Ahlam T. Bdaiwi
Cellular and Molecular Biology,
Vol. 71 No. 3: Issue 3
Abstract
B lymphocyte cells have received considerable attention in recent studies regarding their role in tumor immunity. Tumor Infiltrating B cells (TIBs) are the name that describes the B lymphocyte cells that infiltrate a tumor tissue. Different cellular components interplay in the environment of tumor and modulate the response of antitumor immune dynamically. A Dual role for TIBs is detected in tumor immunity regulation instead of just tumor promotion or inhibition. The present study was performed to evaluate the tumor-infiltrating B lymphocyte and the clinical outcome. Immunohistochemical analysis of B Lymphocytes in stromal/intratumoral regions was performed in 40 OSCC specimens by using CD20 antibodies. Expression of the markers and their relationship with clinicopathological parameters was evaluated by using of Independent t-test and Analysis of Variance (ANOVA) (two-tailed). Data analysis demonstrates a significant association of stromal and intratumoral CD20+ B lymphocyte infiltration with well-differentiated lesions (P < 0.05) and stage I cases (P>0.05). In addition to a significant correlation of stromal infiltration of CD20+B lymphocytes with lymph node metastasis (P=0.01). The results suggest that CD20+ B lymphocytes play an important role in OSCC, where higher infiltration of CD20+ B cells in stromal regions, particularly in cases with lymph node involvement, may be used as a prognostic indicator and may aid in determining whether the use of B lymphocyte as therapeutic targets in OSCC.
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