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Copyright (c) 2025 Hawri Mustafa Bakr
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Role of Toxoplasma surface proteins in host-parasite immune modulation
Corresponding Author(s) : Hawri Mustafa Bakr
Cellular and Molecular Biology,
Vol. 71 No. 3: Issue 3
Abstract
Toxoplasma gondii is an intracellular parasite that evades the host immune system using its surface proteins. These proteins, including SAGs, MICs, and GRA, regulate host immune responses by interacting with immune receptors, modifying immune signaling pathways, and suppressing inflammatory responses. This modulation allows the parasite to survive and replicate within host cells. The study employed various biochemical and immunological methods, such as ELISA, flow cytometry, RT-PCR, Surface Plasmon Resonance (SPR), and co-immunoprecipitation (Co-IP), to assess the effects of these surface proteins on immune responses. Results showed that Toxoplasma surface proteins reduced the production of inflammatory cytokines (e.g., TNF-α) and increased anti-inflammatory cytokines (e.g., IL-10). SPR analyses confirmed direct interactions between parasite proteins and host immune receptors, altering immune-related signaling pathways. These findings emphasize the significant role of Toxoplasma surface proteins in suppressing the immune system and promoting parasite survival and replication. A deeper understanding of these mechanisms could aid in developing new therapeutic strategies and vaccines against toxoplasmosis. Future research could focus on identifying additional signaling pathways and creating targeted interventions.
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