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Copyright (c) 2025 Alexander Blagov, Vasily Kashtalap, Ksenia Lapshina, Amina Karimova, Alikhan Asoyan
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.New strategies for treating Sjogren's syndrome
Corresponding Author(s) : Alexander V. Blagov
Cellular and Molecular Biology,
Vol. 71 No. 4: Issue 4
Abstract
Sjögren's syndrome (SS) is a complex autoimmune disorder characterized by dryness, fatigue, and systemic involvement, with current treatments largely limited to symptom management. This review explores promising new therapeutic strategies targeting specific molecular pathways implicated in SS pathogenesis, including the roles of B cells, T cells, dendritic cells, cytokines, and neuroendocrine factors. We examine recent advances in drug development and clinical trials focusing on novel biological agents that modulate these pathways, potentially offering a more targeted and effective approach to SS treatment. Ultimately, this review aims to provide an overview of these emerging therapies and their potential to improve outcomes for patients with SS.
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